Lander Lab

Last chance to apply to the Cold Spring Harbor #cryoem course this March (application deadline is Jan 15th)! Learn all about sample prep, microscope operation, and image processing at this fun 2-week course @kollmanlab @Jen_Cash_11 @cshlcourses meetings.cshl.edu/courses.aspx?c…

Congrats to our grad students who pitched therapeutic targets at this year's @ScrippsGradPrgm Drug Discovery Shark Tank - particularly Shelby @ShelbyFerrier and Morgan @m_m_gee on their winning proposal to target Cholera toxin subunit B, which raised $4 million!

Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio.

You can now follow us at bsky.app/profile/lander…

The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! biorxiv.org/content/10.110…

Let us know if you recognize this complex

Proof our lab skills are cutting-edge—both at the microscope and the (pumpkin carving) bench! 🎃🔬 #CryoEM #PumpkinScience @scrippsresearch

Ready for the final day of the BPS meeting on 'Emerging Theoretical Approaches to Complement Single-Particle Cryo-EM' in Trieste! 🔬 We had outstanding speakers, great science, and friendly atmosphere. Thanks to @BiophysicalSoc @cecamEvents, @palermo_lab @RommieAmaro @LanderLab!

Apply now and come work at @VanderbiltU with me and my outstanding colleagues in the Center for Structural Biology! Would be thrilled to recruit more #NMR friendly colleagues! 😉🙌 @VanderbiltCSB @VandyBiochem @VUBasicSciences

Mesoscale Explorer molstar.org/me/ Paper out !! Excellent work with @asrmoin @dsgoodsell  and @sehnaldavid doi.org/10.1002/pro.51…

Some thoughts on the current state of single particle cryo-EM map/model validation. (TLDR: preferred orientation remains a big problem, ❤️ Q-scores. There's been progress, but there's still more to do. ) authors.elsevier.com/sd/article/S09…

The registration deadline of the meeting "Emerging theoretical approaches to complement single-particle cryo-electron microscopy" is today! Join us in Trieste, Italy, with an outstanding list of speakers. biophysics.org/2024trieste#/ Pls RT & Apply !

We always thought nucleotide state strictly defined AAA+ conformation, but Jeff Mindrebo's work on mito LONP1 suggests more is at play - substrate interactions also drive protein translocation! Revisiting & rethinking the hand-over-hand mechanism: tinyurl.com/49y7a6h6

Hey all new(ish) structural biology PIs out there - I started a slack workspace geared toward us! If you’d like to join, DM me your email and method(s) of choice, and I’ll add you to the group.

We were incredibly disappointed with the lack of code or executable accompanying the publication of AF3 in @Nature . This contradicts scientific principles of the ability to evaluate, use, and build upon existing work. zenodo.org/records/111798…

There is no such thing as AlphaFold3. There is only alphafoldserver.com. The difference is throttling rigorous scientific and biomedical research.

Jie has an amazing knack of identifying incredibly cool biological systems that give rise to unexpected, impactful findings! Anyone lucky enough to join his group at UVA will receive outstanding mentorship while pursuing inspiring, top-tier research! Please Retweet

Congrats to outstanding UCSD undergrad intern Mason, mentored by the exceptional Alex @alexxsaladbar. Please come back for your PhD at the @ScrippsGradPrgm, Mason!