Costanzo’s Lab
@LabVincenzo
We study basic mechanisms of genome stability maintenance altered in cancer
📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @JCellBiol! Full link here: rupress.org/jcb/article-ab…
The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity. my.corehr.com/pls/uoxrecruit…
🚨 Hot off the press!!! Wanted to share this to celebrate the momentous achievement from the @GiuntaLab and for the human centromere / genomics communities as a whole... more posts to come next week but for now, happy Fourth & happy reading ❤️🧬💻 science.org/doi/10.1126/sc…
Online Now: The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells dlvr.it/TLZtS1
Online Now: The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks dlvr.it/TLZkmH
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance dlvr.it/TKqSww
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!
Truly honored that my career path and laboratory have been featured in the 'Cell Scientist to Watch' interview series. A huge thank you Sara Morais da Silva and @J_Cell_Sci for this wonderful opportunity 🙏
Cell scientist to watch – Hana Polasek-Sedlackova @HanaSedlackova1 In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby. journals.biologists.com/jcs/article/13…
It's out! nature.com/articles/s4158… Structure of the two RAD52 rings forming a spool-like structure at replication fork, rearranging and protecting the fork. Tour-de-force work by Masa Honda and Ali Razzaghi and wonderful (as usual) collaboration with @PietroPichierri 's lab.
🙏 Thank you, @3reak, @LabVincenzo, and Evident, for fantastic collaboration! Special thanks go to the exceptionally talented postdoc Paolo Fagherazzi and the brilliant image analysis specialist Timo Diekmann for their extraordinary efforts! 🙏
Thrilled to share our latest work at @ScienceAdvances. Great collab with Costanzo, Masson, Freire and Reyes labs. HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances science.org/doi/10.1126/sc…
Gaps may be small but meeting will be big! come join us!youtube.com/watch?v=KgBUEc…
Sign up now to enjoy a $200 discount on your registration for the DNA Replication Gaps, Cancer, and Disease event this April in Daejeon, South Korea. Don't wait, as this special offer expires on March 11 at 11:59pm MST. keysym.us/KSDNARep25 #KSNDNARep25 youtu.be/qvZBNKck0z0
We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. cell.com/cell-reports/f…
Congratulations Jenna Whalen on her Nature Cancer pub out today- nick toxicity linked to resection! rdcu.be/d60Td
Join the first Keystone conference dedicated to DNA Replication Gaps, Cancer and Disease! Send an abstract to be selected for a talk. keystonesymposia.org/conferences/co…
Deadlines are approaching for @KeystoneSymp #DNAReplication Gaps, Cancer and Disease, this April in Daejeon! See scholarship, abstract and discount reg dates: keysym.us/KSDNARep25 #KSDNARep25
Check out and join us for an interesting interdisciplinary PhD project! Deadline on 10th of Jan. DNA replication and cancer research 🥹. Please RT
Check our this additional MRC funded PhD opportunity with @AgaGambus on inhibition of PPIs invovled in DNA replication: findaphd.com/phds/project/i…
first-ever meeting on DNA gaps, cancer, and disease in South Korea this April! Join us to explore the latest breakthroughs in DNA repair, replication stress, and cancer therapy. 📅 April 27-30 2025 📍 South Korea Spread the word and stay tuned for updates! 🌟 #DNAGaps #Cancer