RaffaellaSantoroLab
@LabSantoro
We study #epigenetics, #chromatin, #3Dgenome organization and the role of #nucleolus in stem cells and cancer
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors nature.com/articles/s4158…
Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…
Explore RNA's role in epigenetics, DNA repair, transcription & genome organisation - directly with leaders from academia & industry at #GenReg26! Remaining talks will be filled from submissions - register & submit by 04 Sep 2025 to join us in Mexico, March 2026🇲🇽 Speakers,…
Il videoclip più condiviso della storia della televisione italiana, sì, conosco. #TecheTecheTe
Hello RNA World! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @CellReports, @FKHM and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac
The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states dlvr.it/TLCFdR
Isogenic comparison of Airn and Xist reveals core principles of Polycomb recruitment by lncRNAs dlvr.it/TJjsx8
Very excited to share our latest work in @MolecularCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. sciencedirect.com/science/articl…
Tumor-associated zinc finger CTCF mutations which selectively alter its DNA-binding specificity have been reported for the first time by Galina Filippova et. al. almost 25 years ago: pubmed.ncbi.nlm.nih.gov/11782357/
Excited to share our recent paper in Cell Genomics on CTCF mutations!
Our lab has identified a new epigenetic mechanism and a druggable target in #HFpEF. Extremely thankful to my amazing team and our fantastic collaborators! @CircRes @UZH_en @Unispital_USZ @CTECresearch @PaneniLab ahajournals.org/doi/10.1161/CI…
Excited to share our recent paper in Cell Genomics on CTCF mutations!
Schiff: This is not who we are. We don’t bully an ally. We don’t take the side of a dictator. We’re just not what we saw displayed by the President of the United States today. I would say to our allies around the world that what they witnessed today might be Donald Trump, but it…
After Trump''s disgusting and repulsive behavior during his meeting with Zelensky, UK Prime Minister Keir Starmer wastes ZERO time in calling out the fascist shitstain in the White House. 😳👇