Anthony Rullo: chemically modulating proximity

Elucidating Electric Field-Induced Rate Promotion of Brønsted Acid-Catalyzed Alcohol Dehydration | Journal of the American Chemical Society @ChemistryMIT @MIT @yogi_chem @DincaGroup @yuriy_roman @MITChemE pubs.acs.org/doi/10.1021/ja…

Join us for our July #CDCRSeminar with speaker: Prof. Jakob Magolan from the department of Biochemistry & Biomedical Sciences! 📅 Thursday, July 31, 2025 at 4pm 🕓 MDCL 3020 or Zoom 🔗 cdcr.mcmaster.ca/events/cdcr-se…

A new paper reports a strategy to detect binding to Aβ42 oligomers, which is used to select new binders with improved potency nature.com/articles/s4158…

Looking for a great read this weekend? Check out our newest @J_A_C_S pubs.acs.org/doi/10.1021/ja…

Cool paper from Monte Rosa on Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition | Science science.org/doi/10.1126/sc…

Congrats to @PaschkeAK, @ej_meeus, Florin and our collaborators from the pharmacy institute M. Masota and Prof. Nathalie Grob - Late-Stage Diversification of Peptides and Peptide Drugs through Nitrogen Atom Insertion | @ChemRxiv - go.shr.lc/44mL6Kg

[NEW paper!] Proximity-induced O-GlcNAcylation: we showed that a single sugar modification can act as a molecular switch that triggers protein degradation & more!🍬Huge congrats to the OGTAC team!👏Open-Access Article: pubs.acs.org/doi/full/10.10…

Chemistry Stories: Math for chemists, by chemists: new second-year level course: uoft.me/bGL

Michelle Chang of @PrincetonChem and colleagues publish in @NChemBio: “Terminal alkyne formation by a pyridoxal phosphate-dependent enzyme.” Great work! nature.com/articles/s4158…

TWeeP (This Week's Paper): Introducing functional handles to proteins is crucial throughout chemical biology. In @J_A_C_S, the Francis group use megaTYR, a bacterial tyrosinase, to modify Tyr residues with DTT, thus inserting exposed thiols to the target. pubs.acs.org/doi/10.1021/ja…

Overcoming the Hydrolytic Susceptibility of Thiol-Reactive Reversible Warheads through the Development of Substituted Phenyl Cyanoacrylamides | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Diffusion limit and the reactivity/affinity conundrum: implications for optimization and hit finding for irreversible modulators. #JMedChem @bharath_IGC go.acs.org/cN0

Brilliant presentations by @RulloLab @LabRullo group members in the chemical biology division at the nationals #CSC2025 ! Covalent ternary complexes, affinity electrophile mechanisms, reversible covalency , immunotherapy and more !

Happy to share our new paper in @J_A_C_S !! Subcellular Analysis of Fatty Acid Metabolism Using Organelle-Selective Click Chemistry pubs.acs.org/doi/10.1021/ja…

We're excited to share that our recent work on hemiboronic acid-catalyzed, site-selective monophosphorylation of diols and polyols is out now in Organic & Biomolecular Chemistry. Congrats to the team! @genevieveokeefe @DKonoChem @Boron_Chemistry pubs.rsc.org/en/content/art…

🔬Meet Dr. @Faezeh_Jame, a postdoc at @SFU, studying how sugar molecules influence disease. Working in the Vocadlo lab, she is exploring how sugar molecules and the driving enzymes, glycosyltransferases, are involved in health and disease. Read: canadianglycomics.ca/trainee-at-gly…

A new Perspective by Mark Howarth discusses click biology as an analogy to click chemistry, examines reactions using building blocks present in living cells, and highlights opportunities for fundamental research and synthetic biology nature.com/articles/s4158…

Development of a Selective and Potent PRMT4 PROTAC Degrader with Efficacy against Multiple Myeloma in Vitro and in Vivo | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Excited to share our discovery of ACBI4: VHL PROTAC degrader of KRAS(on) mutant e.g. G12R. High ternary-complex cooperativity to the rescue! VHL Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-loaded KRAS(on) Alleles | ChemRxiv - go.shr.lc/4efUF2s

Isomerization of Poly(ethylene glycol): A Strategy for the Evasion of Anti-PEG Antibody Recognition | Journal of the American Chemical Society @uni_mainz pubs.acs.org/doi/10.1021/ja…