Tomas Fiala

@TomFiaLAB

Senior Scientist and Branco Weiss Fellow at ETH Zürich | Supramolecular Chemistry and Chemical Biology

ETH Zürich, Switzerland

Joined October 2021

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554Followers

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Tomas Fiala@TomFiaLAB · Jul 6

TWeeP (This Week's Paper): A cool new tool from the Bernardes lab—non-metallic carbon monoxide-releasing prodrugs. Tertiary aldehydes release CO after a radical trigger. A big step towards mapping out the therapeutic effects of CO. Now out in @J_A_C_S. pubs.acs.org/doi/10.1021/ja…

TomFiaLAB's tweet card. Carbon monoxide (CO) has demonstrated therapeutic benefits in reactive oxygen species (ROS)-rich environments, such as inflammation and cancer. However, the targeted delivery of CO remains challeng...

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Tomas Fiala Retweeted

Nadace Experientia@experientiacz · Jun 26

Ze světa se vrací na svou alma mater, @MasarykUni, kde založí vlastní výzkumnou skupinu. Co ho přivedlo zpět k české vědě? 🧠 A proč bude hledat příčiny vzniku neurodegenerativních chorob? Čtěte příběh Tomáše Fialy, nového držitele start-up grantu. 📌experientia.cz/start-up-grant…

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Tomas Fiala Retweeted

Nadace Experientia@experientiacz · Jun 17

Nadace Experientia zná držitele start-up grantu pro rok 2025! 👨‍🔬 Tomáš Fiala, který aktuálně působí na ETH Zürich, založí svoji výzkumnou skupinu na @muni_cz v Brně, kterou od ledna 2026 podpoří start-up grant Nadace Experientia ve výši 6 000 000 Kč. Moc gratulujeme!

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Tomas Fiala@TomFiaLAB · Mar 30

TWeeP (This Week's Paper): In Biomacromolecules (@MacroJrnls_ACS), @SmritiMukherj20 et al. present a neat way of stabilizing collagen triple helices and inducing their fibrillation via terminal aromatic capping groups. pubs.acs.org/doi/abs/10.102…

TomFiaLAB's tweet card. Developing collagen-mimetic peptides (CMPs) with short triple helices and fibril-forming ability remains challenging. Herein, we stabilized short CMPs (3–6 GPO repeats) by attaching extended aromatic...

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Tomas Fiala@TomFiaLAB · Jul 27

TWeeP (This Week's Paper): another fantastic publication from the Kanai lab in @J_A_C_S. Check out how to generate isocyanates on demand from a stable hydroxamic acid–pyrrolidine conjugate and sulfonyl fluoride for fast protein labeling in live cells! pubs.acs.org/doi/10.1021/ja…

TomFiaLAB's tweet card. Selective bioconjugation reactions, exemplified by bioorthogonal chemistry, constitute a fundamental and broadly applicable tool across diverse fields, enabling precise biomolecular modifications in...

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Tomas Fiala@TomFiaLAB · Jul 21

We have multiple PhD and Postdoc positions open in my new group at Masaryk University. Are you an excellent and motivated candidate interested in organic and peptide synthesis and chemical biology? Get in touch! Start in January 2026. fialalab.com Appreciate sharing!

TomFiaLAB's tweet image. We have multiple PhD and Postdoc positions open in my new group at Masaryk University. Are you an excellent and motivated candidate interested in organic and peptide synthesis and chemical biology? Get in touch! Start in January 2026. fialalab.com
Appreciate sharing!

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Tomas Fiala@TomFiaLAB · Jul 13

TWeeP (This Week's Paper): Cool supramolecular chemistry of bambusuril macrocycles! In @ChemCommun, Heck et al. show strong complexation of the astatide-211 anion. The complex is stable in human serum! Nice progress towards At-based radiopharmaceuticals. pubs.rsc.org/en/Content/Art…

TomFiaLAB's tweet card. Herein, we report a molecular cage allowing strong chelation of the 211At radioanion. Propargylated bambus[6]uril shows good affinity towards iodide and astatide radiohalides, affording promising...

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Tomas Fiala@TomFiaLAB · Jul 1

Interesting atmospheric phenomenon 🌩️ Clear sky, just two white clouds on the horizon with strong lightning. Haven't seen anything like this before. Am I just a weather ignorant or is this really uncommon? 🤔

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Tomas Fiala@TomFiaLAB · Jun 29

TWeeP (This Week's Paper): Introducing functional handles to proteins is crucial throughout chemical biology. In @J_A_C_S, the Francis group use megaTYR, a bacterial tyrosinase, to modify Tyr residues with DTT, thus inserting exposed thiols to the target. pubs.acs.org/doi/10.1021/ja…

TomFiaLAB's tweet card. Site-specific protein bioconjugation methods have enabled the development of new therapeutics and materials, and further development of existing techniques has expanded the compatible library of...

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Tomas Fiala@TomFiaLAB · Jun 22

TWeeP (This Week's Paper): Visualizing sulfite in live cells with zero background? No problem with the sulfite-responsive 19F-NMR probes by Su and coworkers. Now out in @J_A_C_S! pubs.acs.org/doi/full/10.10…

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Tomas Fiala@TomFiaLAB · May 9

Selectively assembling collagen heterotrimers is a challenge. But not for us! Aminopropline-aspartate salt bridges drive the assembly of hyperstable, minimal-length, and special blunt-ended collagen heterotrimers. Now out in @angew_chem! With @LabZenobi. onlinelibrary.wiley.com/doi/10.1002/an…

TomFiaLAB's tweet image. Selectively assembling collagen heterotrimers is a challenge. But not for us! Aminopropline-aspartate salt bridges drive the assembly of hyperstable, minimal-length, and special blunt-ended collagen heterotrimers. Now out in @angew_chem! With @LabZenobi.
onlinelibrary.wiley.com/doi/10.1002/an…

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Tomas Fiala Retweeted

chemistry.unwrapped@chem_unwrapped · Apr 16

🕶️ Sunglasses Helped Pasteur Discover Chirality? 🤯 The same principle behind polarized sunglasses played a pivotal role in one of science’s groundbreaking discoveries. 👇See this phenomenon in action using sugar and polarizing filters! @michal_juricek @UZH_Chemistry @UZH_ch

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Tomas Fiala@TomFiaLAB · Apr 14

TWeeP (This Week's Paper): A very nice review on the role of water in collagen structure and folding has been published in Biomacromolecules (@MacroJrnls_ACS) by Giubertoni and coworkers. Check it out! pubs.acs.org/doi/full/10.10…

TomFiaLAB's tweet card. Collagen is the most abundant protein in the human body and plays an essential role in determining the mechanical properties of the tissues. Both as a monomeric protein and in fibrous assemblies,...

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Tomas Fiala@TomFiaLAB · Apr 8

🐌💞🐌 Snails can only mate if their shell spiral in the same way? Check out the latest @chem_unwrapped video on CHIRALITY to find out! @JuricekLab @pdchemspol @UZH_Chemistry @UZH_ch #chiralityunwrapped

cchemistry.unwrapped@chem_unwrapped · Apr 8

Ever noticed that some things are not the same as their mirror images?🪞That’s chirality! 🐌 And snails take it very seriously—if their shells don’t spiral the same way, they literally can’t mate! 😳 @michal_juricek @JuricekLab @UZH_Chemistry @UZH_ch @UZH_Science #SciCommChat

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Tomas Fiala@TomFiaLAB · Mar 16

TWeeP (This Week's Paper): Protecting groups (PGs) for proteins? Yes! The Barnardes lab brilliantly uses a "lock"-PNA as a protein PG and the complementary "key"-PNA for deprotection via proximity-driven trans-thioesterification. Now out in @angew_chem. onlinelibrary.wiley.com/doi/10.1002/an…

TomFiaLAB's tweet card. A strategy for the conditional activation of therapeutic proteins utilizing removable peptide nucleic acid (PNA) masking groups is presented. Site-specific installation of “Lock”-PNAs containing a...

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Tomas Fiala Retweeted

Morandi Lab@morandilab · Mar 7

Many Congrats to @yannickbraegger, @PaschkeAK, Nima Nasiri, @BenceBBotlik and @Ffelician99 for this masterpiece! Oxidative amination by nitrogen atom insertion into carbon-carbon double bonds @ScienceMagazine, @ETH_DCHAB, @ETH_en science.org/doi/10.1126/sc…

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Tomas Fiala Retweeted

Olalla Vázquez@OlallaLab · Mar 3

What an incredible few days!🎉🎉As the cherry on top, @ValeskaViereckt 👩🏼‍🔬1st paper is out—right after her fantastic presentation at #EPI2025!Exciting new collaborations @Uni_MR with @LabLichtenberg & #MarinaGerhard-many more to come. A huge♥️🙏🏼 for making it possible! #ProfLife

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Tomas Fiala Retweeted

Michal Juricek@michal_juricek · Feb 26

Check out the first two chemistry.unwrapped videos on our YouTube channel! 🎥 You will learn why bread doesn’t taste sweet when it's loaded with sugar 🍞🤯 and how everything that we eat starts with nuclear fusion on the Sun ☀️🌿 @UZH_Chemistry @UZH_ch youtube.com/watch?v=mg9KIs…

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Tomas Fiala@TomFiaLAB · Feb 23

TWeeP (This Week's Paper): Congrats to my colleague Bartosz and @pianowskilab on the nice work on glucose-derived bis-crownether receptors for photo-controlled binding of amino acid esters in water via isomerization of azobenzenes. Now out in @CommsChem. nature.com/articles/s4200…

TomFiaLAB's tweet card. Communications Chemistry - Selective amino acid receptors that operate in aqueous media are of interest for potential diagnostic and sensing applications. Here, the authors report glucose-derived...

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Tomas Fiala@TomFiaLAB · Feb 20

Deadline #PhD position extended until 09.03 - Apply online👇🏼stellenangebote.uni-marburg.de/jobposting/39b… Please RT❤️ - Thanks

OOlalla Vázquez@OlallaLab · Dec 12

📢📢Official release #PhD position #OrganicChemistry at @Chemie_UMR & @mpi_marburg within Loewe consortium #RobuCop 🤖🦠 Apply online 🛜🛜 stellenangebote.uni-marburg.de/jobposting/39b… 📆Deadline 22.12 - please RT♥️🙏

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