PhilippaMelamedLab
@LabPMelamed
Molecular Endocrinology & Epigenetics Laboratory at the Technion
Our latest - great work by Dor @dor_shalev1 with help from @GilGolan73 @YaelmgLAB and others - showing a role for Acvr1c in downregulation of Mkrn3 expression. academic.oup.com/narmolmed/arti…
Looking fowards tmrw to our Cancer Epigenetics symposium. @BiologyTechnion @TechnionLive @technion All welcome.
Together with @ReizelTzachi and Dvir Aran @biologytech
We had a great trip yesterday to Caesarea with @TechnionLive Harvey prize laureates Profs Stephen Baylin, Andy Feinberg and Peter Jones
We had a great trip yesterday to Caesarea with @TechnionLive Harvey prize laureates Profs Stephen Baylin, Andy Feinberg and Peter Jones
Beautifull work - congrats to all
🧵 1/ New preprint! How do transcription factors (TFs) use intrinsically disordered regions (IDRs) to find their target sites? biorxiv.org/content/10.110… #TranscriptionFactors #IDPs #SingleMolecule #Biophysics
Joint ESPE-ESE congress in Copenhagen, delighted to see two of my favourite scientists (and people) with Prof Anna Cariboni speaking on signalling in HH and Prof Philippa Melamed chairing @LabPMelamed @CariboniLab #connectingendocrinology2025 #connectingendocrinology
Joint ESPE-ESE congress in Copenhagen, delighted to see two of my favourite scientists (and people) with Prof Anna Cariboni speaking on signalling in HH and Prof Philippa Melamed chairing @LabPMelamed @CariboniLab #connectingendocrinology2025 #connectingendocrinology
Two wonderfull talks on the genetics of pubertal timing and minipubery by Sasha @drsashahoward at our annual meeting @IsrEndoSociety. And a great meeting organized by @DannyBenZvi
#WorldHormoneDay לקראת יום ההורמון הבינאלומי נתונים חשובים ומעניינים על הורמונים ומחלות אנדוקריניות
Join us to the Spring Conference of the Israel Endocrine Society, April 27-28/4/25 in Tel Aviv! Early registration fares ends soon ies.org.il/events/annual5…
Combining CRISPR activation and interference capabilities using dCas9 and G-quadruplex structures academic.oup.com/narmolmed/arti…
The earlybird and abstract deadline for the Alternative Nucleic Acid Topology (AlterNAT) Meeting, organised in collaboration with @RoySocChem @NucleicAcidUK, is 10 May! Submit your work for consideration and register now to save £50: ow.ly/EsLG50V947n
Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new @ScienceAdvances study. scim.ag/3EOMHQ4
Latest paper from the lab, analyzing ALPSAC data @CO90s by amazing PhD student Maya Sudman @MS
Association of childhood DHEAS concentration, pubertal development and DNA methylation at puberty-related genes by Maya Sudman @LabPMelamed et al EJE Volume 191, Issue 6, December 2024 Full paper 👉 doi.org/10.1093/ejendo… ESE Members free via 👉 my.ese-hormones.org
Human genomic DNA is widely interspersed with i-motif structures | The EMBO Journal embopress.org/doi/full/10.10…
We are so proud to share our latest work on G-quadruplexes in the XDP neurodegenerative disorder, led by our postdoc @GiuliaNicolez, in collaboration with @ccxdp @dmonchaud and @GSchotta 👉academic.oup.com/nar/advance-ar… @SaraNRichter_ @DMM_Unipd @LMU_Muenchen @ICMUB @MassGenBrigham
Congrats - looks very interesting
Check out our new study just published in @GenomeMedicine! Important findings for medical geneticists 👨⚕️🧬🔬 #3dgenome #chromatin #gigantism #GPR101 #TADopathy #X-LAG @ENEA_Young @ENEAssoc @EYEScientists @EnGioi_Endo
So this is the first publication of Tal's beautiful PhD work, now out in @CMLSjournal. Thanks for a wonderful collaborations with @akaplanz @ArnonHenn @Ella_Preger @Sujaynk13 and work from our PhD students @MSudman and @gilgolan73
Happy to share our latest work on the non-coding elements regulating Lhb which encodes the pituitary gonadotropic hormone that controls reproduction, involving an i-motif, eRNA and adjacent lncRNA through distinct mechanisms in a sex-specific context. link.springer.com/article/10.100…
A beautuful study - so happy to have been involved - with my PhD student @GilGolan73
Happy to share our latest work on the non-coding elements regulating Lhb which encodes the pituitary gonadotropic hormone that controls reproduction, involving an i-motif, eRNA and adjacent lncRNA through distinct mechanisms in a sex-specific context. link.springer.com/article/10.100…
Wouldn’t it be great to test how individual transcription factors engage with their motif in the nucleus? We tried exactly that in a study lead by Ralph (@RalphSGrand) and Marco (@marco_heffler) now out in Molecular Cell authors.elsevier.com/sd/article/S10…. 1/7