Krishna Aragam
@KrishnaAragam
Preventive Cardiologist. Population Genetics Researcher. Boston sports and basketball enthusiast. @MGHHeartHealth @BroadInstitute
Our study led by R. Bhattacharya & @cmarnell92 shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are: 1. Hypertension 2. CAD polygenic risk score ahajournals.org/doi/10.1161/CI……
Today, we are thrilled to announce that @VerveTx has entered into a definitive agreement to be acquired by @EliLillyandCo From 2018 to 2025, Verve moved a new concept (a one-dose future for the treatment of atherosclerotic cardiovascular disease) and a new medical technology (in…
HUGE congrats to graduating @MGHCVFellows @tigerstatdoc @SumeetKhetarpal, both 🌟 preventive cardiologist-scientists, for receiving @BWFUND Career Awards for Medical Scientists!! We are thrilled that @tigerstatdoc will stay with us @MGHHeartHealth @broadinstitute & also…
@VerveTx team is thrilled today to present initial data from the Heart-2 Phase 1b clinical trial of VERVE-102, an in vivo base editing investigational medicine targeting PCSK9 And the emerging product profile of VERVE-102 (for patients receiving ≥50mg total RNA dose): a. A…
Defended my master’s thesis few days ago! Couldn’t have reached this point without continuous guidance from my mentor @aklfahed, colleagues @tigerstatdoc @CFAndersenMD @mchonig and many people who have supported me so far. Looking forward to continue doing this!
Excited to share our latest publication where we identified a novel and essential role of TTN enhancer. Thanks to @MerajNeyazi @KGkatzis @zoltarany @ArunSharmaPhD @ChrisToepfer @GOuditResearch @williampu66 @AxelVisel @BrighamWomens @harvardmed @bwhcvls and all others #Genetics
Titin, the largest known human protein, is vital for normal heart muscle contraction. @yurikim_mdphd, @MerajNeyazi & team @harvardmed now discover an intron-mediated enhancer that regulates TTN gene expression and cardiomyocyte contractility: jci.org/articles/view/…
Exciting to see a series of human genetic observations we made a few years back now moving into therapeutic space ALK7 loss of function mutations, better body fat distribution, reduced T2D risk --> @ArrowheadPharma siRNA, pre-clinical data confirming above, to Phase 1 this year…
Delighted to share our study by @tigerstatdoc with @aklfahed on adding in a CAD polygenic risk score to clinical factors to boost CAD risk prediction, particularly for recovering premature CAD events ahajournals.org/doi/10.1161/CI… @Circ_Gen
The relationship of high polygenic risk scores to coronary artery disease disease for extent of atherosclerosis and presentation with heart attack/unstable angina jamanetwork.com/journals/jaman… @JAMANetworkOpen @aklfahed @KelvinS_MD @pnatarajanmd @patrick_ellinor
How lean is your muscle? Hot off the press 🔥@escardio We show fatty muscle (IMAT) ⬆️ heart disease risk (beyond fat under skin, around heart or in liver) @anachsouza Muscle quantity AND quality💪 ⬆️⬆️🫀cardiometabolic risk 👀 👇 bit.ly/42maQXZ bit.ly/3Ce2iYC
Increased amounts of fat in skeletal muscle [intermuscular fat], a marker of inflammation, is associated with an increased risk of major cardiovascular events. From an observational study of >600 participants with PET scans, followed for 6 years (a first) academic.oup.com/eurheartj/adva……
Is slow heart rate or conduction block heritable? Check out our new meta-analysis @NatureGenet incl common (~1.3m individuals) + rare (~400k) variants for bradyarrhythmias and conduction dz. Co-led w/ @LuChenWeng @joeltramo @JurgensSean @broadinstitute ! nature.com/articles/s4158…