KnowlesLab Cambridge
@KnowlesLabCamb
Interdisciplinary and interactive group of scientists working on microfluidics, protein biophysics and protein misfolding diseases.
New paper from @Catherine_k_xu @KnowlesLabCamb & collaborators reports secondary nucleation as not only the key source of a-synuclein oligomers, "but also the main mechanism of aggregate formation"; The process can occur under neutral pH & ionic strength nature.com/articles/s4146…
Our work on predicting the composition of biomolecular condensates — cellular complexes that regulate processes, such as signalling, gene expression and stress response — together with a comprehensive proteome-scale atlas is now published in @NatureComms nature.com/articles/s4146…
Thermodynamic insights into trigger factor broad substrate specificity - fantiastic work by Therese together with Quentin, Pavan, Tadas and @SchneiderMatth in a collaboration with Christodoulou and Cabrita groups at UCL is out now: science.org/doi/10.1126/sc…
Introducing a quantitative nonspecificity score for clinical-stage antibodies - great work by Therese Herling and @HAusserwoeger in an exciting collaboration with Novo Nordisk is now published: pnas.org/doi/10.1073/pn…
Fundamental insights into the influence of sheer forces in amyloid formation - great work by @eaandrzejewska and @mus_greta led by @Emil_Axell and others from the Linse lab is now out: pnas.org/doi/10.1073/pn…
Check out our newest publication on creating custom architectures inside biomolecular condensates - congratulations Nadia, @DaoyuanQian219, Tomas and others together with the Weitz lab and @vanhest_lab! nature.com/articles/s4428…
How condensates sustain pH gradients and their potential role as emergent electrochemical microenivorenments - great work by @HAusserwoeger, @rob_scrutton, Tomas, @CM_Fischer and others together with @HymanLab, Alberti Lab and @novonordisk is now out: biorxiv.org/content/10.110…
Outcome of a great collaboration with @VendruscoloLab is now published! Well done @eaandrzejewska.
Super psyched to see this published at last! We demonstrate a novel approach to slowing alpha-synuclein aggregation in #Parkinsons. A massive thank you to the @VendruscoloLab, @KnowlesLabCamb, Caughey, Ghetti and Sormanni labs. cam.ac.uk/research/news/… nature.com/articles/s4158…
Check out the great work of @georg_meisl and Alex!
Check out our new PNAS paper pubmed.ncbi.nlm.nih.gov/38652742/ Using a method originally developed in astronomy, we determine the half lives of all proteins in a cells, in a single set of experiments. Congrats to Alex & everyone involved on a really cool paper! @KnowlesLabCamb @PNASNews
Tuomas gives his inaugural talk as he takes on the position of a 1920 Professor in Physical Chemistry. Congratulations! @ChemCambridge
Exciting start to Day 2! Tuomas Knowles, Professor & Head of the @KnowlesLabCamb at @Cambridge_Uni, kicks off the day with a captivating talk on “Functional artificial materials through self-assembly of natural peptides and proteins”. #SupraLife #SecondSchool #ConferenceDay2
Check the latest work on albumin-drug conjugates! Great collaboration with Bernardes group. Well done Tuuli! pubs.acs.org/doi/full/10.10…
Check our new paper on Ab42 self-replication! Well done @georg_meisl, great collaboration with @SaricLab !
New🌶️: Amyloid self-replication occurs on small & rare “catalytic sites” on the fibril. Work of Samo, who came for @EUErasmusPlus and stayed for MS & PhD...some things take time;). Great fun with @KnowlesLabCamb @MichaelsLabETH @georg_meisl 🪩pnas.org/doi/10.1073/pn…
Congratulations to Tanu for giving a talk on her PhD work in the liquid-liquid phase separation field! #BPS2024 by @BiophysicalSoc
Check our work on Selenium-silk antimicrobial agents! Well done Elli, @ZToprakcioglu and Akhila. pubs.rsc.org/en/Content/Art…
So thrilled to share the results of an exciting collaboration with @PappulabWashU and the Hyslop lab. Congratulations @DaoyuanQian219, @HAusserwoeger and the team! You can read more about it here: biorxiv.org/content/10.110…
Congratulations to Tomas, Nadia, @HAusserwoeger, @KadiLiisSaar, @TimWelsh_ , @DaoyuanQian219, @GeorgKrainer and @AlexBoRNA on publishing their work on the antimicrobial peptide mechanisms of action through LLPS! nature.com/articles/s4146…
🗣️ Tuomas Knowles, Professor & Head of the @KnowlesLabCamb at @Cambridge_Uni 🇬🇧, is a plenary speaker @#SupraLife #SecondSchool!🤩 Tuomas will elucidate the molecular mechanisms & dynamics of protein aggregation to generate biofunctionality & understand neurological disorders!