Julian Streit
@JulianStreit3
Postdoctoral researcher studying protein folding and biophysics
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @MSFTResearch AI for Science. #ML #AI #NeuralNetworks #Biology #AI4Science biorxiv.org/content/10.110…
New preprint with Benjamin Lang, @kriwacki, @j_christodoulou, and @m_madan_babu ! biorxiv.org/content/10.110… Protein Dynamics at Different Timescales Unlock Access to Hidden Post-Translational Modification Sites #bioinformatics #compchem #folding #proteindynamics
In press!! NMR & MD simulations reveal how non-native contacts stabilise a key transient intermediate in the lysozyme amyloid cascade. @MinkooAhn @JulianStreit3 @chris_waudby @ttwlodarski @FigueiredoAm @j_christodoulou @UnivCamPharm For CMD ❤️ advanced.onlinelibrary.wiley.com/doi/10.1002/ad…
Very happy that this story found its home at @PNASNews pnas.org/doi/10.1073/pn…
Teaser of our most recent manuscript, preprint in a few days! :) #potassiumispurple #kchannels #directknockon
Rationally designing 19F probe pairs was key to determining the structures of protein folding intermediates on the ribosome in our latest preprint. Our design strategy is now published in @NatureComms ! nature.com/articles/s4146… #NMRchat #compchem #compbio
Out now! How to rationally design 19F labels to study structures of large biomol complexes, incl in cells. Using engineered ring currents, and designed with MD and AF. With co-first author @JulianStreit3, Saifu Daya & @j_christodoulou #nmrchat #compchem biorxiv.org/content/10.110…
Structures of protein folding intermediates on the ribosome biorxiv.org/content/10.110… #biorxiv_biophys
Visualising nascent polypeptide chains emerging from their parent ribosome with cryo-EM and all-atom MD simulations.
Cryo-EM, and integration with MD simulations, of nascent proteins on the ribosome. Congrats Alki and @ttwlodarski and co-authors!
New preprint on the thermodynamics of co-translational protein folding!
New preprint! We find the ribosome’s electrostatic charge defines how nascent proteins fold. Using all-atom MD and 19F NMR. Led by @JulianStreit3 with @CsBurridge, Joel Wallace, @chris_waudby, @LisaCabrita @j_christodoulou #nmrchat #compchem #compbio doi.org/10.1101/2025.0…
Check out our study - NMR & MD simulations reveal how non-native contacts stabilise a key transient intermediate in the lysozyme amyloid cascade. @MinkooAhn @JulianStreit3 @chris_waudby @ttwlodarski @FigueiredoAm @j_christodoulou @UnivCamPharm For CMD ❤️ biorxiv.org/content/10.110…
Tailored NMR experiments combined with a new DNN provide high-resolution spectra of aromatic side chains and accurate uncertainty estimates - enabling quantifications of dynamics and kinetics doi.org/10.1126/sciadv… @ScienceAdvances @gogulan_k @bhu_vaibhav @TheCrick #NMRchat
Out now! How to rationally design 19F labels to study structures of large biomol complexes, incl in cells. Using engineered ring currents, and designed with MD and AF. With co-first author @JulianStreit3, Saifu Daya & @j_christodoulou #nmrchat #compchem biorxiv.org/content/10.110…
Happy to share our new preprint describing how #compchem can aid in 19F #NMR experimental design to study large complexes and proteins in cells - with co-first author @sammyhschan , Saifu Daya and @j_christodoulou biorxiv.org/content/10.110… #NMRchat
Meet the CALVADOS RNA model on bioRxiv or on 🦋
Do you like CALVADOS, but also proteins with folded domains? If yes, check out Fan’s paper on the CALVADOS 3 model Several changes since the first preprint including a new parameter set and the application to changes in folding stability in condensates dx.doi.org/10.1002/pro.51…
Check out the research briefing about our recent paper in @Nature. We describe how the ribosome shapes folding of its nascent proteins by integrating NMR experiments with all-atom molecular simulations: nature.com/articles/d4158… #NMRchat #compchem #compbio #proteinfolding #ribosome
Thrilled to share that our latest work in the Christodoulou lab is now published in Nature! nature.com/articles/s4158… Thanks to everyone who contributed @Ivana_Bukvin, @sammyhschan, @ttwlodarski, @FigueiredoAm , @chris_waudby, @LisaCabrita, @anaiscassaignau, @j_christodoulou!