Johan Jakobsson
@JakobssonLab
Director at Lund Stem Cell Center, Professor of Neuroscience at Lund Univ, Stem cells, Epigenetics, microRNA, Reprogramming, Transposons, ERVs, LINE-1
#TransposonDay2025 New manuscript from our center to which we contributed. Provides a mechanistic explanation for how L1s are silenced during early human development. doi.org/10.1101/2025.0…
Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics
New preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons biorxiv.org/content/10.110…
In our latest preprint, we introduce the first human cell-type-specific brain aging clocks from high-precision postmortem samples. Using single-cell transcriptomics, we uncover distinct aging patterns and new insights into neurodegeneration. #BrainAging biorxiv.org/content/10.110…
New preprint from our lab! Great collaboration with the labs of Karolina Pircs and Csaba Kerepesi from Budapest. We built molecular aging clocks for the human brain using single-nuclei RNA-seq data. doi.org/10.1101/2025.0…
New pre-print from our lab. Led by the outstanding @aniada97 and Raquel Garza. LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development. biorxiv.org/content/10.110…
Interestingly, naïve mice constitutively (without any immunization or infection) secrete IgM and IgG that bind to the surface antigens of ERVs, such as the envelope and glycogag antigens (4/)
📰 A recent @NatureComms study by a @Lund_Stem team led by @ch_douse reveals how DNA methylation & the HUSH complex work to silence repetitive #DNA and protect genomic stability, providing new insights for #aging and disease research. Read more ⤵️ stemcellcenter.lu.se/article/new-re…
🎉 Congratulations to @Lund_Stem's Joan Yuan (@TheYuanLab) and Filipe Pereira (@CellReproLab) who have received 61 million SEK from @KAWstiftelsen for research into immunological long-term memory and reprogramming of tumor cells. #Immunology Read more ⤵️ stemcellcenter.lu.se/article/yuan-a…
🧵Highlights from the @Lund_Stem Annual Retreat 2024! Last week, we brought together 170 members of our research community for two days of networking, collaboration, and science talks in Båstad, Sweden! It was our biggest retreat ever! 🙌 #ScientificNetworking #StemCellResearch
The most well-deserved price and a wonderful recognition to the importance of the non-coding genome. Why is not everyone working on microRNAs?
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
BREAKING: This year's #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun. The pair have been recognised "for the discovery of microRNA and its role in post-transcriptional gene regulation." Stay tuned for more from @nature
…. and only around 14 hours until the famous call from Stockholm. Here’s the phone I’ll use. If you expect the call, please stay alert @ around 9.30-10 CEST tomorrow!
Now that the dust has settled..I will say this much, I’m livid. The more I find out about Stefano’s betrayal..the more angry I become. I chaired the search that hired him. We had many other wonderful apps to choose from. The hurt that he caused in Brenda’s lab and his own /1
Science is built on trust. What happens when someone destroys it? My first feature for @_TheTransmitter investigates the emotional and existential fallout for one lab in the aftermath of a misconduct case. thetransmitter.org/science-and-so…
Settled in the beautiful island of Capri, the CNR-IGB/EMBO workshop on Brain Organoids&Single-Cell Technology is just around the corner! Don’t miss out on the cutting-edge insights! @CNRsocial_ @EMBOevents cnr.it/it/evento/1943…