JP Lab

Pleased to share that our CENP-32 story is now published! ⁦@JPLab_⁩ , Jun Liao, Erica Davis and Bill Earnshaw labs and several clinicians. Led by Avinash Dharmadhikari (CHLA, UCLA), @Alba_Edinburgh and Sheraz Khan. @SBSatEd ⁦@GeneCenter_LMU⁩ nature.com/articles/s4146…

In our latest #PLOSGenetics paper, @SatyaDev2064 and coauthors report that the dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spin ... dx.plos.org/10.1371/journa… @jncasr @bose_institute @IndiaDST @EdinburghUni @KaustuvSanyal

Now online. ⁩ Distinct roles of spindle checkpoint proteins in meiosis - ScienceDirect With some updates from the preprint. Congratulations ⁦⁦@Anu_Mukherjee96 and as always thanks for Christos Spanos for his proteomics expertise. sciencedirect.com/science/articl…

H4.V is Oryza-specific. It is a gatekeeper to promote deposition of active H4K5Ac during salt stress, a common stress for semi-aquatic rice. Big thanks to @JPLab_ @jp_arulanandam for beautiful CryoEM structures, Fred Berger @gmivienna for discussions, Vinoth Lab @NCBS for biochem

Excited about #Fungal pathogens and the interplay with the host? Fully funded PhD in our lab @EdinUni_IRR @zje_institute @edin_EID. Excellent team, including @JPLab_ @ewjwallace and teaching in China! Deadline 31st January. Please RT! biomedical-sciences.ed.ac.uk/postgraduate-s…

Exciting news! 🎉 After a long journey, my postdoctoral research is finally published! 🌟 While we often hear about telomere depletion with age, have you ever wondered what happens to our centromeres? 🤔 In this study, we show how centromeres weaken and ways to reactivate it !!

Join us in Stresa, Italy for the amazing @embo Chromosome Segregation and Aneuploidy organized by ⁦@SteSantaguida⁩ ⁦@ELogarinho⁩ ⁦@BenDavidLab⁩ ⁦@Foijer_lab⁩ ⁦@McclellandLab⁩ and myself. Registrations are open now! meetings.embo.org/event/25-aneup…

Check out our latest structural paper about human OGG1 processing DNA lesions within nucleosome core particles, in collaboration with Chuanzheng Zhou's lab. #DNArepair #cryoEM nature.com/articles/s4146…

Get in touch if you are interested in joining us in Galway!

When kids are shrunk (remember Honey I Shrunk the Kids) or cells are tiny, use the power of Expansion Microscopy. This is what @Reza_Hashim21 et al. from @KaustuvSanyal lab @jncasr did in collab. with @Dey_Gautam lab @embl. Hashim explains how U-ExM expands fungal pathogens!

#Chromosomes in early prometaphase are longer, have a more granular surface, and lack a primary constriction. From Cisneros-Soberanis, Simpson, Earnshaw et al. @WTcell: hubs.la/Q02Mx5G40 #StructuralBiology #Mitosis #CellDivision

Thrilled to share our new paper in @ScienceMagazine, in which we identify p62/SQSTM1 as a critical regulator of micronuclei 🧬🔬🧫 #ScienceResearch science.org/doi/10.1126/sc…

An absolute honor to co-chair the Centromere Biology GRC together with @iaincheeseman! Great science, lots of first-time attendees & speakers, massive trainees participation, speakers lunch tables, and a stimulating power hour. The future is bright for this community!🔥💪🧬🔬

Excited to reveal our new chemical-genetic system to inhibit PP2A-B56 phosphatase. We use this to characterise its substrates and roles during mitosis. This is a simple yet powerful approach to inhibit any enzyme/protein relying on SLiM-based interactions biorxiv.org/content/10.110…

Two postdoctoral positions available in my group to investigate centromere structure, function and evolution - please get in touch if you are interested! jobs.cam.ac.uk/job/47525/ jobs.cam.ac.uk/job/47569/

Great to this Mis18 story in its published form! Fantastic collaboration @UhnsooC @DinaSchneidman @jurirappsilber @OwenDaviesLab Reshma Thamkachy @bethan_medina Sang Ho Park @WTcell @GeneCenter_LMU embopress.org/doi/full/10.10…