Dave Hughes

New career chapter 🔓 | Thankful for my mentors and support network after this 10 year post doc journey, which I wouldn’t change for the world 🌎. Excited for all the new challenges ahead 💪🏼. omrf.org/2025/07/17/omr…

🧵1/8 We’re excited to announce our new @CellReports paper, “Intramuscular adipose tissue restricts functional muscle recovery,” where we defined the functional impact of IMAT on muscle regeneration. tinyurl.com/mpuyadcp

Fantastic work just just out as a @biorxivpreprint | DNA Methylation Ageing Atlas Across 17 Human Tissues Very honoured to contribute to this work led by @macsuej & @nir_eynon group Very exciting data! biorxiv.org/content/10.110…

🚨Our latest paper is out! Check it out. onlinelibrary.wiley.com/doi/10.1111/ap…

Morphological differences in myofibre size and shape: A comparative study of the soleus, gastrocnemius, triceps brachii and vastus lateralis in humans and mice onlinelibrary.wiley.com/doi/10.1111/jo…

The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch biorxiv.org/content/10.110…

Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions | #myotwitter pubmed.ncbi.nlm.nih.gov/40663393/

Hey Muscle And Metabolism Folks on Twitter, @LykkeSylow and I are looking for a Postdoc who is interested in applying for a prestigious @DDEA_Denmark fellowship with us. More details in the picture attached. Please share widely! @MYOTWlTTER

Skeletal Muscle-Specific Deletion of E3 Ligase Asb2 Enhances Muscle Mass and Strength | #Myotwitter pubmed.ncbi.nlm.nih.gov/40641155/

Sarcomerogenesis: "sarcomere division is triggered by tension and local sarcomere damage... and muscle contractions. Sarcomere divisions repair damaged sarcomeres, ensure their mechanical integrity, and synchronize sarcomere addition..." @SchnorrerL science.org/doi/10.1126/sc…

Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction | #Myotwitter | ⁦@phc_mesquita⁩ et al. ⁦@AM_OMRF⁩ pubmed.ncbi.nlm.nih.gov/40638619/

Muscle AMP deaminase activity was lower in Neandertals than in modern humans pubmed.ncbi.nlm.nih.gov/40640132/

Truly a team effort led by Grant Laskin. A project that started out as a “sticky wicket” ended with something I hope others find useful pubmed.ncbi.nlm.nih.gov/40632504/

I am excited to have contributed to this review on muscle proteomics from @BenParkerLab. We cover key technical considerations & recent advances in capturing its temporal, fiber type & stem cell proteomes. nature.com/articles/s4432…

Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise ahajournals.org/doi/10.1161/CI…

Our latest study connects reduced NR4A3 expression with physical inactivity and indicates that NR4A3 downregulation in human muscle has adverse effects on glucose metabolism and protein synthesis. Congrats to @JonoSmith01 @DrBMGabriel @NicoPillon & team! sciencedirect.com/science/articl…

Skeletal muscle proteomics: considerations and opportunities nature.com/articles/s4432…

🚨Just over a month to register #BSRA2025. With our largest number of abstracts ever, this is looking like an amazing meeting! bsra.org.uk/events/74th-an… 🗓️Deadline Friday 8th August

Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice nature.com/articles/s4146…

Congratulations to Amy Bongetti, @CaldowMarissa, Dr Yasmine Ali Abdelhamid and @GordonSLynch for their new review paper, "Evaluating skeletal muscle wasting and weakness in models of critical illness". @UniMelb @UniMelbMDHS @TheRMH #muscle #ICU portlandpress.com/clinsci/articl…