Holmes1618
@Holmes1618
Lifelong learner. Eternal optimist. Investing by day, self-medicating by night, researching rapamycin. Shitposting on stocks, options, and politics. HelloX!
How to read the Hematology Panel: Focus on the ratio of Neutrophils and Lymphocytes, or the NLR ratio. Ideal NLR ratio is 1 to 1.50 (longevity). If you take rapamycin for longevity, if your ratio is below 1, you may be too high on the dose. Most people take 6mg weekly these…
Say it, H1B. Say it to GenZ. Say it to tech workers who lost their jobs to their H-1 B replacement. Say it to new grads having a hard time finding any entry-level tech jobs. You guys have let those people down bigly. Six months in, no one addressed the issue, not even Trump.…
Huge drop in $TXN, a black stain in a darling sector of $SMH. Demand pull forward by tariff, Chinese competition, and weak auto demand: What are the implications for $TSLA tonight, if any? Also report tonight: $GOOGL, $IBM, $NOW, $QS, $CMG, $CSX
Good chart on Rapamycin, Metformin, and Aspirin. potential CRM compounds (like metformin, rapamycin, resveratrol) and understanding their mechanisms of action (e.g., targeting insulin signaling, mTOR, AMPK, sirtuins, stress pathways, free radical regulation) to replicate CR…
NEW REVIEW: Molecules that mimic calorie restriction: metformin, rapamycin, resveratrol, spermidine, aspirin link.springer.com/article/10.100…
Great list.
Been working on creating a table of (mostly US-based) monopolies, duopolies, and oligopolies. Not everything is a perfect fit but wanted to create something to start tracking these sorts of companies. Any suggestions on stuff to add/remove/change etc? Nothing is set in stone.
Selegiline, the new kid on the block from an old world?
Some interesting post on Selegiline here
Rapamyin Podcast @PeterAttiaMD @mkaeberlein @danawhite A new era of longevity science: models of aging, rapamycin trials, biological clocks Rapamycin Key Updates (2025) Core Mechanism Restores dynamic mTOR signaling: Reduces baseline inflammation, enhances autophagy, and…
Rapamycin Update: Professor Andrea Maier from National University of Singapore Study: 6-month trial in 150–200 healthy adults (40–60 yrs) testing rapamycin’s impact on: Epigenetic clocks Inflammatory cytokines Functional metrics (strength, cognition, pulse wave velocity) Goal:…