Sheffield Hearing Group

Hi everyone, just to let you know that we will no longer be posting on X, but you can follow us on Bluesky 🦋: bsky.app/profile/hearin…

That's a wrap for the Paris adventure! We all had a fantastic time at the Pasteur institute and hoping it'll be the start of something great between the two groups. Now back to the UK, I think my electrophysiology rig misses me 💜

We've been working on a very exciting project: developing a novel approach combining surgery and #twophoton imaging📷to investigate #calcium signalling generated spontaneously in the cochlear sensory epithelium📷in live neonatal mice 📷: nature.com/articles/s4146… @NatureComms

🎅Well it wouldn't be a holiday season if I didn't take my awful photoshop skills for a spin (5 people added, wildly varying effort). This is us signing off for the year, and what a year it's been! See y'all in a few weeks, here and at the new @hearingshef.bsky.social account! 🎄

Happy #MicroscopyMonday!📸Here we have one of Charlie’s first immunos from the start of his PhD! This image captures the apical turn of the organ of Corti. Nucleis are labelled with DAPI(blue) and hair cells with myosin-7a(green), a vital protein for both hearing and vision!👀👂

Did you know that we fund research to understand more about tinnitus so we can develop and find ways to treat it? Next week is #TinnitusWeek. Find out more about the research that we're doing: bit.ly/42vIngo

Happy #MicroscopyMonday, everyone! Today we have a brightfield image of some inner hair cell stereocilia, courtesy of Sam 🔬.

Today's paper spotlight comes from Ana I. López-Porras and was published in December last year. This beautiful paper adds some understanding to the role Myo15 and the hair cell transducer current plays in remodelling stereocilia! Definitely worth a read!🔎pmc.ncbi.nlm.nih.gov/articles/PMC11…

Happy #MicroscopyMonday ! Here we have an amazing image from Charlie showcasing the organ of Corti! Two different types of DNA damage are highlighted in green (arrow) and magenta (filled arrow), and blue marking cell nuclei. Such a fascinating glimpse into cellular dynamics! 🔬🧬

Howdy all, to diversify our socials a tad we have a shiny new Blue sky account! We will of course keep posting on here in parallel moving forward, but if you were eyeing up a move to BlueSky you'll have company 💜 Find us with the same username or click: bsky.app/profile/hearin…

The lab's PIs are currently in Paris at the L'Institut Pasteur! Full day of science ahead and establishing collaboration is the name of the game; always good to keep groups talking!

Happy #MicroscopyMonday, everyone! 🎉 This week, Char shares a stunning confocal image of beta III tubulin labeling in spiral ganglion neurons from a P9 cochlea dissection. Look at those beautifully detailed somas and projections!

Happy new year all! Today's paper spotlight is one of ours and was published in PNAS just last week, in this manuscript we show that mature cochlear hair cells use Myo7a INDEPENDENT mechanisms to maintain their resting transducer current! Full publication: pnas.org/doi/10.1073/pn…

Santa’s sleigh flies at 3810x the speed of sound to spread joy to kids around the world. The supersonic shockwave could cause a lot more serious damage than merely “dashing through the snow” if his magic wasn’t here to protect us. #FunFactFriday Image from @FrewerEngineers

Can you hear me now? insight.jci.org/articles/view/… Preclinical work from Andrew O’Connor et al. shows that AAV-mediated delivery of Myo7a restores inner hair cell function to improve hearing. @HearingShef @neuroshef