Hanqing Liu
@Hanq_Liu
I am a Postdoctoral Fellow in the Ecker lab at the Salk Institute for Biological Studies
Thrilled to share our latest work from @JoeEcker lab, using cutting-edge snmC-seq3 and snm3C-seq technologies to generate 301,626 methylomes and 176,003 mC+3C multiome profiles from 117 dissected regions throughout the adult mouse brain. (1/n) biorxiv.org/content/10.110…
Why is social isolation associated with negative valence while social grouping elicits positive reward? How to animals know they are alone or together? Our latest work uncovers two distinct hypothalamic populations underlying social homeostasis. biorxiv.org/content/10.110…
Our first dataset investigating the chromatin conformation and methylation dynamics during human brain development with > 50,000 sn-m3C profiles from the frontal cortex and hippocampus, led by Matthew Heffel, Jingtian Zhou, @YiZ001UC_, Dong-Sung Lee, and @kangchenghou.
Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus biorxiv.org/cgi/content/sh… #biorxiv_genomic
Happy to see our paper in print -- we show how accounting for gene co-expression can help with robust estimation of enhancer-gene links. Congrats to @FangmingXie @EthanArmand2 and our peerless co-authors, incl @chongyuanluo @JoeEcker @HongkuiZeng Bing Ren and more!
Robust enhancer-gene regulation identified by single-cell transcriptomes and epigenomes dlvr.it/Sqvk60
Future students/postdocs/collaborators—if you are interested in my work, please check out my (temporary) research website. Happy to discuss any potential projects that we could work on together in the future! tatsuyanobori.com
So excited to share our latest work with @ecallaway & @JoeEcker using Epi-Retro-Seq, combining retrograde virus tracing & single-cell methylation profiling, to link epigenetic cell types to their long-distance projections. 🧠🔬 (1/8)biorxiv.org/content/10.110…
Super excited to share our latest work from @JoeEcker lab, where we generated a single-cell spatiotemporal gene regulatory atlas of plants under pathogen attack by combining time-resolved single-nucleus multiomics and spatial transcriptomics🧬🌱⏳🦠🔬1/n biorxiv.org/content/10.110…
My colleagues and I have been using SkyPilot since August. It saved us a lot of time and 💰 establishing some of the biggest future-looking pipelines on GCP (and potentially on any other cloud). A great tool to invest your time if you are interested in using cloud platforms.
Introducing SkyPilot: Run ML and Data Science jobs on any cloud, with massive cost savings. 🚀 Run jobs on any cloud ⏰ Get GPU/TPU/CPU in 1 click 💵 Reduce > 3x cost skypilot.co Read blog: medium.com/@zongheng_yang… 🧵1/
Our single nucleus multi-omic method snmCAT-seq is now published in @CellGenomics. @FangmingXie from @emukamel lab has developed a cross-validation approach using multi-omic info to determine the optimal cluster number. cell.com/cell-genomics/…