Alessandro Gozzi (@gozziale.bsky.social)
@Gozzi_Ale
Senior scientist @IITalk 🧠 🐁 Neuroimaging, brain (dys)connectivity and autism @ERCGrantees
How do cortical perturbations affect fMRI connectivity? Not necessarily as one would expect! Our new work @NatureComms shows that cortical inactivation may unexpectedly INCREASE fMRI connectivity! rdcu.be/cHKie 🧵below explains how. Spoiler: δ oscillations are key! 1/n
Benchmarking methods for mapping functional connectivity in the brain | doi.org/10.1038/s41592… What is the best FC metric? led by @liuzhenqi0303 in @naturemethods ⤵️
1/ Six years in the making! Our preprint on SORDINO fMRI is out. We're sharing the raw data and sequence to facilitate brain-wide mapping in awake, behaving rodents. If this could be useful to your colleagues and friends, please help spread the word! biorxiv.org/content/10.110…
Our latest work is online today @ScienceAdvances ➡️Brain connectivity in carriers of high risk mutations for #autism and #schizophrenia U-turns across adolescence (hyper -> hypo) ➡️This switch is driven by synaptic remodeling science.org/doi/10.1126/sc… Full explainer below 👇
➡️What's the significance of brain dysconnectivity in developmental disorders? ➡️And what are its underpinnings? To address these questions we mapped connectivity in carriers of high-risk mutations for autism and schizophrenia➡️tinyurl.com/ytuca74u Here's what we found🧵 1/n
Scientists have uncovered how puberty reshapes brain connectivity in 22q11.2 deletion syndrome, a genetic condition linked to autism and schizophrenia. The findings highlight how changes in synapses and brain connections may shape social behavior and… dlvr.it/TLZJSm
First tweet on an exciting new manuscript online @NatureNeuro - in collab with @LucinaUddin and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠... #neuroscience #neuroimaging #fMRI Read here: rdcu.be/ek01F
🚀 I will be presenting about our 🧠 🧲 BrainCAP toolbox at #OHBM in two weeks! 🎉 I'm on the job ⚡ market this year for a tenure-track assistant professor position in #psychiatry and relevant depts, and would love to meet you and chat about research and opportunities! 👇👇👇
We will present "BrainCAP: an open-source neuroimaging toolkit to analyze 🧠 co-activation patterns" at #OHBM2025 in an #Oral session! A cool collaboration with Samuel Brege, Zailyn Tamayo, Youngsun Cho (@YalePsych) and Catie Chang (Vanderbilt) - See you all in Brisbane! @OHBM
Study how local brain manipulations impact whole-brain connectivity 🔬 1 Fully funded PhD at @cimec_unitrento, supervisor: Dr. Alessandro Gozzi, Istituto Italiano di Tecnologia 📌Apply by June 5, 2025 🔗 phd.unitn.it/drcimec #Neuroscience @Gozzi_Ale
🧠 Use functional ultrasound imaging #fUSI to map brain networks mice - Fully funded PhD opportunity at @cimec_unitrento! Supervisor: Dr. Alessandro Gozzi, Istituto Italiano di Tecnologia 📌 Apply by June 5, 2025 🔗 phd.unitn.it/drcimec #Neuroscience @Gozzi_Ale
🚨 #OHBM2025 attendees, the Keilholz MIND lab (specifically me, Lauren and @ShellaKeilholz ) are organizing a symposium! Come Thursday morning June 26th to learn about the neural mechanisms of FC from a great lineup of speakers - @ShihYYI , @e_deguz , @SeongGi_Kim and Nan Li!
#Puberty may alter #BrainConnectivity in chromosome 22q11.2 #DeletionSyndrome, increasing autism and schizophrenia risk. Changes in synapse density and GSK3-beta protein are key factors, mouse study indicates. @ScienceAdvances doi.org/g9d6zj medicalxpress.com/news/2025-04-p…
After a long journey, our paper is officially out in PNAS! 🚀 Huge thanks to the team — excited to finally share it with the world. Check it out: pnas.org/doi/10.1073/pn…
Nice to see our preprint featured! Thanks @callimcflurry and @_TheTransmitter for the excellent coverage!🐭🧠 👇 #neuroscience #autism
An analysis of 20 autism mouse models point to two subtypes: One displaying out-of-sync brain activity and impaired synaptic pathways, the other with too much synchrony and dysregulated immune pathways. By @callimcflurry thetransmitter.org/spectrum/too-m…
Breathing isn’t just for life—it’s a brain pacemaker! This excellent review reveals how each breath sends sensory waves that globally synchronize neural networks - with implications for "functional connectivity". Congrats to the authors! 👉 doi.org/10.1038/s41583…
Outcomes for the first 60 MDD patients treated at our clinic @QLDNeurostimCen with robotically delivered & fMRI-personalized rTMS MADRS response=74%, remission=53% for RCT patients EXCITED to see fMRI moving from research to real-world clinical use! karger.com/pps/article/do…
Vittani, Lee, Wang, Hiraoka, et al. KI mouse expressing red fluorescent blood In situ SpyTag/Catcher attachment of biosensor ECS SpyCatcher to capture BBB leak doi.org/10.1101/2025.0… We hope this method is useful to a wide range of the biology community.
There are two subtypes of autism: brain hypoconnectivity & hyperconnectivity. 🧵1/9
Report: fMRI of 20 mouse models of autism (n=549 mice) clustered as hypo- & hyper-connectivity subtypes. In human autism (940 cases; 1036 controls), 25% had analogous hypo-/hyper-connectivity subtypes. Will be interesting to learn developmental timing & environmental effects.
Can we use brain scans to identify biologically distinct "autisms"? And If so, how? In our latest cross-species study 🐭👨we dive into these questions! Find out more here 👇👇 biorxiv.org/content/10.110… Thread below 🧵 1/n
Proud of this work led by @Gozzi_Ale and Marco Pagani following 10y or r&d, massive multi-labs collaborations and lots, lots of scans. See the inspiring 🧵 below 👇🏼
Can we use brain scans to identify biologically distinct "autisms"? And If so, how? In our latest cross-species study 🐭👨we dive into these questions! Find out more here 👇👇 biorxiv.org/content/10.110… Thread below 🧵 1/n