Ian Shih
@ShihYYI
Brain imager, Professor and Vice Chair for Research @UNCneurology, Director @camri_unc, Associate Director @BRIC_UNC
1/ Six years in the making! Our preprint on SORDINO fMRI is out. We're sharing the raw data and sequence to facilitate brain-wide mapping in awake, behaving rodents. If this could be useful to your colleagues and friends, please help spread the word! biorxiv.org/content/10.110…
Congrats to this year's Bruker MRI Award Winners, presented at the @ISMRM. 1st place was awarded to Tzu-Hao Harry Chao @UNC for "Mapping Inter-Brain synchronization in Awake, Socially Interacting Mice, SORDINO Sequence for Hyperscanning". 👉goto.bruker.com/440KyKb #BrukerMRIAward
This is really interesting work, @Chuang_Lab! Congrats!!!
Our 6-yr efforts is finally published on Nature Communications! We discover a neural pathway that regulates the glymphatic system. Its deficit in aging and dementia may result in the pathology. This suggests new targets for diagnosis and treatment. nature.com/articles/s4146…
New Cellular Source of fMRI Signals 🧲🧠: Activation of somatostatin interneurons induces astrocytic calcium signaling, which drives delayed vasodilation and enhances layer-specific fMRI signals. @CNIR_IBS @NatureComms nature.com/articles/s4146…
Very much looking forward to the opportunity to share more animal work at @OHBM. Thank you, @MeyerBaese, Lauren, and @ShellaKeilholz, for organizing this!
🚨 #OHBM2025 attendees, the Keilholz MIND lab (specifically me, Lauren and @ShellaKeilholz ) are organizing a symposium! Come Thursday morning June 26th to learn about the neural mechanisms of FC from a great lineup of speakers - @ShihYYI , @e_deguz , @SeongGi_Kim and Nan Li!
We are excited to highlight one of our finalists, in no particular order. This innovative study uses a custom-designed 3D-printed cradle and SORDINO-fMRI to image two interacting mice. Voting closes on April 18th, so vote today! Visit goto.bruker.com/42lHnNg @ISMRM #ISMRM
💡Optogenetic stimulation of projection terminals is often thought to preferentially modulate downstream targets. In our recent fMRI study led by @LiMingHsu2, we compared cell body and terminal stimulations, showing that potential antidromic effects shouldn’t be overlooked.👇
Optogenetic stimulation of cell bodies or axonal terminals triggers similar brain-wide activation patterns