Aleksandra Filipovska
@FilipovskaLab
New paper from us on the in vivo role of the LRPPRC/SLIRP protein complex and its crucial role in mammalian mtDNA gene expression: academic.oup.com/nar/advance-ar… Congratulations @RubalDiana for great work! Thank you to all coauthors for a very nice collaboration.
Our story about FASTKD5 is now published at @NAR_Open. It was an amazing collaboration with @hauke_hillen and @Antonio41949078 labs. doi.org/10.1093/nar/gk… FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
This poster is a must have for labs working on #MCS! A guide through the work of so many outstanding labs (apologies if we did not cite your work). Hang it in your office or lab, it will please your eyes and inspire your mind! Kudos to the driving force Antigoni Diokmetzidou! -LS
In their Cell Science at a Glance article, Antigoni Diokmetzidou & Luca Scorrano @LabScorrano summarise the mitochondrial contacts characterised in mammals, the mechanisms underlying their formation, and their principal functions. journals.biologists.com/jcs/article/13… #JCSMitoSI #OpenAccess
Dysfunctional mitochondria trap proteins in the intermembrane space | The EMBO Journal embopress.org/doi/full/10.10…
It takes two to TANGO2! TANGO2 binds the heat shock protein crystallin alpha B to prevent aggregation of the intermediate filament desmin and its loss models TANGO2-deficiency disorder Many thanks to our team, collaborators and reviewers. rdcu.be/epI3p #metabolism
Silencing mitochondrial gene expression in living cells | Science science.org/doi/10.1126/sc…. Wonderful that our paper is out now in Science. A big thanks to LD Cruz-Zaragoza and the team, @warscheidlab & @JakobsLab .
📢 Hunter Meeting abstract submissions close 5pm AEST today! @ANZSCDB is proud to have joined forces with the Hunter Meeting 2025. Please encourage your colleagues, postdocs and students to submit their abstracts today! Link: huntermeeting.org.au/abstract-submi…
Ready to make breakthroughs in gene editing and mitochondrial biology in sunny Western Australia? Join our vibrant team as a Research Associate or Research Fellow. Expertise in cryo-EM, cell imaging, or mammalian genetic screens is highly desirable staff.curtin.edu.au/explore-career…
The peer-reviewed version of our paper on human tRNA 3' processing is now published in @NatureSMB. Many thanks to the reviewers for their constructive comments! nature.com/articles/s4159… See also the very nice related work by @BMartinHallberg @no1gv: embopress.org/doi/full/10.10…
Happy to share a new preprint, in which we describe the mechanism of human tRNA 3' processing. We show why the RNase Z ELAC2 acts as a monomer in the nucleus, but forms a multi-subunit complex in mitochondria. Plase see 🧵 by @BhattaArjun2p for details! biorxiv.org/content/10.110…
New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice! academic.oup.com/nar/article/do… #RNA #mitochondria #mtDNA
Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact. biorxiv.org/content/10.110… Muscle mito nanotunnels 1/3🧵
Mini reunion of team 'Mito Dysfunction' at @CellSymposia #CSMito2024! Wonderful to catch up with Aleks @FilipovskaLab from my PhD days in the Murphy Lab @Mito_Redox @MRC_MBU
Great to catch up with Helena Cochemé and Aleksandra Filipovska in Sitges #CSMito2024 ...both are doing great running their own labs - despite doing their PhDs in my lab...
📢Registrations are now open for the ANZSCDB NSW Meeting! Scan the QR code to secure your ticket 🎟️👇
Better CRISPR base editors! More efficient nicking of the unedited DNA strand improves the ability to edit hard to reach bases. @ACSSynBio pubs.acs.org/doi/10.1021/ac…
Our latest preprint! Some beautiful cell biology in this one. "Presynapses are mitophagy pit stops that prevent axon degeneration" biorxiv.org/cgi/content/sh… Discoveries into the cell biology of of mitophagy in axons, a disease mechanism, and a potential therapeutic avenue. 1/2
Out today! We find that an epigenetic modification (6mA) to the mitochondrial genome (mtDNA) influences lifespan and the heritability of mtDNA mutations to the next generation. It implies that epigenetics determines genetic composition in future offspring. cell.com/cell-metabolis…
We are excited to announce the 12th ANZSCDB South Australia meeting taking place on October 16, 2024! Join us for insightful talks from @McGlinnLab, @CedricBardyLab, and @Lisa_M_Nic at @unisa. Don't miss this packed event! #devbio #science #cellbiology
🥳🚨Paper Alert🚨🥳 Excited to present our latest work on #Opa1 in this newly published paper @ScienceAdvances by @sahola6 and @LPazurek. We present here two new mouse models with impaired Opa1 processing. 1/🧵 science.org/doi/10.1126/sc… #mitochondria #mitochondrialdynamics @MPIAGE
Check out our latest pre-print with @hauke_hillen and @VuckoviccAna, where we show that FASTKD5 joins RNase P and RNase Z in processing mitochondrial RNA. FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites biorxiv.org/content/10.110…
You can read this article by @FilipovskaLab for free for the next 50 days at the following link: authors.elsevier.com/a/1jNoN3jDgWq3…