Slava Epelman

Our latest study, led by @Homaira_H. Hard to study #macrophages (MFs) in early human heart development (no tissue). Homaira integrated human ES-derived-MFs into beating cardiac microtissues & improved🫀function. rdcu.be/dHbj0. #cardioimmunology #regeneration.

Scientists @PMResearch_UHN led by @Schwartastic have developed CellNEST, a powerful AI tool that maps how cells talk to each other. By detecting complex signals between cells, it could lead to new ways to target tumours and stop disease progression. 🔗uhnresearch.ca/news/pinpointi…

Canada is stepping up in global #HealthInnovation. @UHN is launching the Canada Leads 100 Challenge - a bold initiative to recruit 100 top clinician-scientists from around the world. The goal? Transform Canada’s research economy.🔬

Congrats @Homaira_H for winning best poster at #bcvs2025 @AHAScience. You do @UHN_Research @PMunkCardiacCtr @TBEP_UofT @trogersresearch @CIHR_IRSC proud!

"Given the strength of the scientific evidence and the urgency of the public-health costs, we urge the scientific community and policy makers to recognize the addictive potential of ultra-processed food and its consequences." nature.com/articles/s4159…

Our Collaborative Centre for Clinical Research is leading the IA45 initiative with a goal that all clinical research studies can be activated in 45 days. Good for patients, good for research progress.

Join us on Oct 2nd for our 10th Annual #HeartFailure Symposium! 🎉 💭 10-year retrospective & future insights 🎙️ Workshops, panels & social hour 🎟️ FREE for partner institutes (with a promo code) Register 👉 tedrogersresearch.ca/symposium/ #HFSymposium #HeartResearch #TRCHR

We can predict a person's risk of coronary artery disease better than ever before. Cover of new @NatureMedicine regarding our @ScrippsRTI @scrippsresearch recent paper @ATorkamani nature.com/articles/s4159…

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) nature.com/articles/s4158…

Analyzing human myocarditis at the tissue transcriptomics levels, with two different platforms, we found that the disease is characterize by widespread molecular perturbations independent of leukocyte-rich foci. Myocarditis is not so patchy after all! biorxiv.org/content/10.110…

BRD4 acts as a pH sensor to tune inflammation bit.ly/3IOIyNU

Too much waste. Too much waiting. Too much #scanxiety. Happy to share that we received @CIHR_IRSC funding for the JUSTIFY RCT (NCT06930521), which will test a novel approach to reduce mandatory routine heart imaging during HER2+ #breastcancer treatment. #CardioOncology

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s4158… #OpenAccess at @Nature @CNIC_CARDIO #microbiome #CVD

Excited to share a milestone published in @NatureMedicine from our decade-long effort to build The Human Phenotype Project, a unique longitudinal cohort with unmatched depth of clinical and multi-omic profiling, enabling truly predictive, personalized medicine. Led together with…

Check out the News and Views from Marina Terekhova and myself discussing the very cool paper explicitly unlinking aging and inflammaging: nature.com/articles/s4358… Here is original paper by Franck et al: nature.com/articles/s4358…

We’re @BlaineyLab sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible with individual and combinatorial perturbations, diverse SpCas9-based technologies, and multiple high-content, single-cell readouts. biorxiv.org/content/10.110…

Humanized mouse models enable the use of reverse genetics to study immune gene functions in human disease @ScienceAdvances @LShanlab science.org/doi/10.1126/sc…

Very happy to share this perspective published in @NatRevImmunol with Alex Leunig, @MatteoGianesel2 @ScottRussoPhD on communication and connection between #nervous and #immune systems. Was fun to put this piece together! 🧠 🦴 🩸 👇🏻 nature.com/articles/s4157…

Imaging of macrophage accumulation in solid tumors with ultrasound @NatureComms nature.com/articles/s4146…

A supplement to @ScienceMagazine on the Heart. Essays from @IcahnMountSinai @SinaiCards @SinaiHeartBlood physicians and investigators. Fantastic to work with @DLBHATTMD @EricJNestler & many others! Frontiers of Medical Research: Heart | Science | AAAS science.org/content/resour…

The immune system and brain are uniquely associated with healthspan and longevity, the latest insights from organ clock proteomics @NatureMedicine @wysscoray nature.com/articles/s4159…