Marty Taylor, MD PhD
@DrMartyTaylor
@BrownMedicine GI pathologist, cancer & transposon biologist, dad, climber, woodworker, photographer, track&field @Princeton ‘05 & @HopkinsMedicine ‘15
Thrilled to announce our paper @Nature, >10 yrs in the making! I led an amazing team to finally crack structures and mechanisms of LINE-1, with implications for cancer, autoimmunity, and other diseases. We made a video abstract with @visualscience narrated by my mentor @JefBoeke
So excited to share our story revealing structures, functions and adaptations of the human LINE-1 retrotransposon, an ancient genetic parasite that has written 1/3 of the human genome and is implicated in cancer, aging, & autoimmunity. Now out in @Nature nature.com/articles/s4158…
science.org/content/articl… Really cool article today in @ScienceMagazine about transposons and efforts across the field to target LINE-1 in cancer, Alzheimers, lupus etc! Our work featured among @AkankshaThawani @MustelinTomas @davetingmgh @bengrbm @john_sedivy @bess_frost @rome_tx
Excited to share I've been selected as the 2025 Rita Allen Milton E. Cassel Scholar. This award honors the memory of a longtime President of the Rita Allen Foundation. I am very grateful to Foundation for the support and recognition of our work and ideas. ritaallen.org/stories/2025-s…
Happy Holidays and Best Wishes for 2025 from #LegorretaCancerCenter @BrownUCancer @BrownMedicine @BrownUniversity @BrownUnivHealth @oncodaily Much progress to build upon for the people of Rhode Island @GovDanMcKee @MiaForRep @SenLouDiPalma @SenJackReed @TheCancerLetter @theNCI
Rare & outstanding career opportunity #LegorretaCancerCenter @BrownUCancer @BrownMedicine @BrownPathology @BrownUnivHealth @BrownUniversity Physician-Investigator, Physician-Scientist or Scientist, Cancer Biology More info & application information: nature.com/naturecareers/…
Great to have Dr. Marty Taylor as a colleague here at @BrownUniversity and to hear about his exciting elucidation of molecular mechanism by which mTORC2 activates Akt at today’s #LegorretaCancerCenter @BrownUCancer Cancer Biology Program meeting @BrownMedicine @rwsobol…
Marty Taylor's exciting elucidation of mTORC2 - @weldeiry @BrownUniversity @BrownMedicine @rwsobol @bcarneiro7 @SeanLawler20 @SenduraiMani @ShiOnaCo @DawsonStemCell @SheldonLHolder @DrSGraff @drdonsdizon @LiangChengMD @JerryAzzoli #OncoDaily #Oncology oncodaily.com/url/123376
Congrats @MangusoLab and Bardeesy labs on an exciting new story linking mobile element activity and innate immunity to the interferon response in a thoughtful and insightful way in this important clinical context!
Our latest paper with the Bardeesy lab @MGHCancerCenter out recently in Science. We describe a novel immune MOA for inhibitors of mutant IDH1 involving the upregulation of transposable elements that are sensed by the cGAS-STING pathway. science.org/doi/10.1126/sc… Explainer🧵
Our latest paper with the Bardeesy lab @MGHCancerCenter out recently in Science. We describe a novel immune MOA for inhibitors of mutant IDH1 involving the upregulation of transposable elements that are sensed by the cGAS-STING pathway. science.org/doi/10.1126/sc… Explainer🧵
16-YEAR-OLD QUINCY WILSON JUST POSTED A 44.37 4x400m SPLIT!!!🤯😱
Very excited to be a part of Team PROSPECT aiming to prevent early onset CRC with an amazing global team of researchers, led by @AndyChanMD and @yincaoScD, converging to meet one of the #CancerGrandChallenges sponsored by @CRUKresearch and @theNCI
Marty Taylor, a key member of our Gastric Cancer Interception Research Team @MGH_RI makes his pitch as a Maverick Finalist @SU2C #SU2C2024Summit to further his research on LINE-1/ORF1p mechanisms
Excited for the poster session at #SU2CScienceSummit and to share our work on the LINE-1 transposon and its role in cancer diagnostics and mechanisms.

Researchers from @MGHPathology and colleagues discover that structural analysis and inhibition of human LINE-1 ORF2 protein reveals novel adaptations and functions, in a @nature study. doi.org/10.1038/s41586…
In the Spotlight from the latest issue— Noninvasive and multicancer biomarkers: The promise of LINE-1 retrotransposons, by @Orel_Doucet and @retrogenomics. bit.ly/4aLz7bS @ircaninstitute @inserm @uca_research @CNRS
youtube.com/watch?v=amryk1… Really cool video on LINE-1 and our work on ultrasensitive detection of Orf1p. I love their description of the total lack of creativity in naming the LINE-1 proteins. Orf1=“Protein McProtein Face”. aacrjournals.org/cancerdiscover…
Thanks @Faulkner_Lab for the kind word and recognition of our work!
My pick for "the" mobile DNA paper of 2023 is actually two studies published back-to-back @Nature reporting the long-sought structure of L1 ORF2p _and_ fundamental insights into the mechanism by which L1 jumps. Amazing work. 1/n nature.com/articles/s4158…
Check out this great review by @CarlosMendezPhD and @KathleenHBurns !
Check out our latest review | LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunities by @CarlosMendezPhD. Our thanks to @GenesDev. genesdev.cshlp.org/content/early/…
... is it reasonable to note "awarded my own bobblehead" on my biosketch? ... 😂 Happy holidays, everyone!
The lab got @KathleenHBurns a gift for the holidays...
Check out our latest review | LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunities by @CarlosMendezPhD. Our thanks to @GenesDev. genesdev.cshlp.org/content/early/…