Daniel Mandel, MD

Let’s @DOIT_trial ! Great work lead by @TotoMynell! @StrokeBern @StrokeAHA_ASA @FishingNeurons @janpurrucker @EspnSaxKristoff @Teddyyhwu @WorldStrokeEd

Soon we will ALL be giving IV TNK to stroke patients on DOACS. The drumbeats are pounding. Here is yet another comparative effectiveness study showing lower ICH and better mRS outcomes among DOAC pts given lytics compared to those who did not. ahajournals.org/doi/abs/10.116…

8. So let’s be blunt: UCLA is a state-run hospital system The Chargers are a privately owned NFL team Why the hell is one sponsoring the other? There is no scenario where this benefits patients….

watching a baby grow is such a ridiculously great peak life experience

As a neurologist, I see the term "dopamine" everywhere: dopamine fasting, dopamine hits, dopamine culture. It's become a shorthand for low-effort pleasure. But the real story is far more complex and fascinating. Here’s a thread on what we actually know 🧠

Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy jamanetwork.com/journals/jama/…

#MondayTip #DWI_negative AIS 📊Meta-analysis, 3,236pt➡️6.8% had clinical diagnosis of AIS w/DWI (-) 🔑Post. circulation is key: 5x greater odds of (-) DWI vs anterior strokes ⏰Timing & size matter ☝️While DWI is highly sensitive, it can still be falsely (-) in selected AIS cases

When you ask ChatGPT to create an image for one of the most insane malpractice cases you’ve ever read…. 😬😬😬

Detailed update on @neuralink

Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST) - The Lancet thelancet.com/journals/lance…

Check out this review on perioperative stroke. It is important to think abt stroke risk in patients undergoing surgery as these stroke increase mortality and morbidity. There are several things that could be done to mitigate this risk. Be on the lookout for a prediction score 😳

Misdiagnosed,misinterpreted or not recognized.With initial polypharmacy excellent outcomes

This place is truly awful but then I go over and check out BlueSky where AOC is treated like the messiah and X doesn't seem quite so bad any more

Why do patients have trouble answering the question "What do you mean by dizzy?" Here is my answer in a 6 minute video. youtu.be/V1ZRHVk6bMI

Pleased to contribute to article in @NeurologyToday on implications of the ECST 2 study and information related to the SCORE Registry. Final results of @CREST2_Study will need to be added to the analysis in the near future @ESOstroke @AANmember journals.lww.com/neurotodayonli…

138 drugs in the Alzheimer's pipeline 📈 - 9% growth from last year - 74% target the disease itself (not just symptoms) - 182 trials actively recruiting worldwide Key shift: We're moving BEYOND amyloid to 15 different disease targets. This is what progress looks like.

Can we pause the politics to just say a prayer for the children of Mark and Melissa Hortman.

Glucagon-Like Peptide-1 Receptor Agonists and Risk of Nontraumatic Intracerebral Hemorrhage in Patients With Type 2 Diabetes | Stroke ahajournals.org/doi/10.1161/ST…

Zero-degree head positioning for acute LVO patients is a protective maneuver to maintain clinical stability in the pre-thrombectomy phase while awaiting definitive treatment. ja.ma/4jKjyEE

This trial in NEJM may look like a quiet optimization in stroke care. It’s not. It’s another chapter in a two-decade turf war—that emergency medicine lost. nejm.org/doi/full/10.10…