Stephan A Mayer

1/ So now it's the cataclysmic TTM -2 trial, just published in @NEJM. How can a world changing trial like HACA published in 2002 now be effectively reversed almost 20 years later? I will explain. nejm.org/doi/full/10.10…

Asymptomatic Hemorrhagic Transformation After Thrombectomy Is associated with substantially worse clinical outcomes neurology.org/doi/10.1212/CP…

in this large observation study 12% of pts with a ruptured AVM developed vasospasm. Three risk factors 1. Younger age 2. Female 3. Intraventricular hemorrhage This met analysis is primarily;y rep[resented by a paper by our group at @WMCHealth @nymedcollege…

Transfusion Strategies in Neuroanaesthesia and Neurocritical Care: A Review journals.lww.com/co-anesthesiol… You have a poor grade SAH patient with asymptomatic vasospasm. What's your transfusion trigger (mg/dl)?

70% of patients with autoimmune encephalitis experience seizures during their hospitalization. The biggest risk factor is periodic epileptiform discharges. sciencedirect.com/science/articl…

Minimally invasive surgical evacuation confers a mortality benefit in patients with moderate-sized putaminal hemorrhages A retrospective single center propensity matched analysis of only 66 patients, but provocative given the negative findings for MIS for deep bleeds in ENRICH…

The Large-Core Paradox explained here. How can MCA stroke patients presenting with large lucencies and low CBV regions benefit from thrombectomy? Here’s a thoughtful review. ahajournals.org/doi/abs/10.116…

An important feature of early brain injury after poor grade SAH is global cerebral edema. Dynamic Contrast–Enhanced MRI can quantify blood brain barrier disruption in this entity. ahajournals.org/doi/abs/10.116…

Nice review of the role of MMA embolization in the management of chronic subdural hematoma neurology.org/doi/10.1212/CP…

This is fabulous. It takes over 1800 overnight vital sign assessments among Neurology floor inpatients to generate one clinical actionable finding. Let your patients sleep! neurology.org/doi/10.1212/CP…

Greater Postthrombectomy contrast staining on CT calculated using the ASPECTS score correlates with worst functional outcome. Not a shocker, but this might be useful for prognostication. ahajournals.org/doi/abs/10.116…

In this real world study of ESUS patients with AIS, anticoagulation was found to be associated with a reduction in recurrent stroke, as opposed to anti-platelet therapy, among those with left ventricular wall motion abnormalities neurology.org/doi/10.1212/WN…

In this clinical trial of LVO STROKE patients — TNK prior to thrombectomy resulted in better outcomes and a higher rate of pre-ANGIO recanalization than thrombectomy alone nejm.org/doi/full/10.10…

Left Atrial Diverticula Detected on Cardiac CT in Patients With Acute Ischemic Stroke: in this provocative pilot study, these small outpourings were related to an increased risk of recurrent stroke. ahajournals.org/doi/full/10.11…

The Impact of Intracranial Blood Clearance on Brain Edema as a Predictor of Delayed Cerebral Infarction Following Subararachnoid Hemorrhage karger.com/ced/article-ab…

This is a great review of post-extubation dysphagia (PED). Why should you care? PED is associated with an increased risk for aspiration pneumonia, malnutrition, decreased quality of life, prolonged ICU- and hospital LOS and increased morbidity and mortality. We need better…

Few things are more momentous than seeing one’s fellow graduate. I used to think academic success was measured in case volume & publications. But over time, I’ve realized the true legacy is mentorship. Watching a fellow grow over 24 months—from their first cautious steps in the…

This is a breakthrough study that forges a new future — POC biomarkers for identifying #ICH in the prehospital phase. Rapid Diagnosis of ICH with GFAP Levels on a Point-of-Care Device (DETECT) @neurology #curingcoma neurology.org/doi/10.1212/WN…