Doc Edge
@DocEdge85
Assistant professor in quantitative and computational biology @USC. Genetics, evolution, and a bit of statistics.
Excited to see this out! Fast, powerful methods for single cell mapping using count based models
Excited to present our work on developing jaxQTL, a new single-cell eQTL mapping tool that improves power and robustness in identifying sc-eQTLs using count-based models. See details in threads 🧵 medrxiv.org/content/10.110…
I'm thrilled that my lab at NYU is now supported by an NIH MIRA grant! I'm looking to hire 1-2 senior lab members (outstanding postdoc candidates or experienced staff scientists) with expertise in computational and statistical methods in human genetics or genomics. Please share!
Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects act in sets”, a great effort led my PhD student @JolienRietkerk, and performed together with collaborators @andywdahl, @AndrewSchork, @jonathan_flint1 etc. Thread 1/n
New preprint with Guy Sella on the question: what is polygenicity? biorxiv.org/content/10.110…
One of my favorite categories of thing is "guy decides to spend decades on an insane, idiosyncratic, solo art project of staggering scope". Other entries include the Watts Towers, Coral Castle, Forestiere Underground Gardens, Le Palais Ideal
this guy spent 21 years building a miniature version of nyc consisting of almost a million buildings, the full model is 50 feet long and 30 feet wide, and he first announced it on tiktok like this:
latest paper from the lab led by PhD student Gilia Patterson. Gilia has developed a spatially explicit deep learning method for close kin mark recapture that we think will be extremely useful for conservation biology biorxiv.org/content/10.110…
Mutation-selection-drift balance models of complex diseases biorxiv.org/content/10.110… #biorxiv_genetic
When should adaptation arise from a polygenic response versus few large effect changes? biorxiv.org/content/10.110… #biorxiv_evobio
I went on WBUR today to talk about the grant terminations and the importance of basic medical research wbur.org/news/2025/05/1…
In the right conditions, antibiotic resistance can happen extremely fast. Here is an example from my own work of bacteria overcoming an antibiotic in just eleven days in a giant petri dish: 1/
This entire line of research, after being repeatedly selected in rigorous open national competitions for funding, was cut this week as collective political retribution x.com/baym/status/19…
Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab
Hanania advocated passionately against "race mixing" for years, so he knows what he's talking about here. But it's worth adding that race-IQ obsessives also tend to make very poor predictions about the future. Let's review ...
I explain the intoxicating effect on some people of thinking about race differences in IQ and how it leads people to go crazy. Stay off drugs.
In population #GENETICS, Q-ST and F-ST calculations help compare the amount of trait differentiation on one or more traits in genome-wide genetic variants. Using simulations Liu and @DocEdge85, show the effect of various choices made while computing Q-ST. buff.ly/313bkfU
In a new #GENETICS research, @Dandan_Peng, Mulder, and @DocEdge85 evaluate the performance of several ancestral recombination graph (ARG) estimation methods used for determining the historical time course of a population-mean polygenic score. Read more: buff.ly/Xr9nFjB
My paper about type I error rates in Qst/Fst comparisons is now published in @GeneticsGSA. Check it out here: academic.oup.com/genetics/advan…
New work from my lab, led by graduate student @janisl98. Janis studied type I error rates in Qst/Fst comparisons (1/n, link to preprint below)
VERY excited to announce a pre-print that represents the culmination of several years of work*: “On ARGs, pedigrees, and genetic relatedness matrices” doi.org/10.1101/2025.0… Led by @BrieucLehmann with contributions from @epigenci @LukeAnderTroc @jeromekelleher @petrelharp
Our daughter's wonderful teacher and her family lost everything in the Eaton fire. If you can spare a few dollars to help out, I would be grateful gofundme.com/f/help-the-lim…
1/7 🧬 New Preprint Alert: Our study highlights the risks of using divergent reference genomes in population genomics. The choice of reference genome can skew key inferences about demography, diversity, and selection. Read on for insights! biorxiv.org/content/10.110…
In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox: For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
University of Superabundant Coaches
BREAKING: USC football has been placed on probation by the NCAA for exceeding the permissible number of countable coaches in 2022 and 2023, the Los Angeles Times reported Tuesday morning. The University was fined $50,000.