Department of Immunobiology at UNIL
@DIB_UNIL
Official account of the department of immunobiology (DIB) at the university of Lausanne @UNIL. Formerly department of biochemistry.
The whole DIB would like to congratulate Pascal Schneider for his Lifetime Achievement Award! More info: unil.ch/news/174904271…
We are excited to announce the 2nd edition of the Symposium on the Immunobiology of Pattern Recognition Receptors, October 1-2, 2025, Lausanne, Switzerland🇨🇭! Attendance is limited to 150 participants. Registration and info: wp.unil.ch/immunobiologys… @DIB_UNIL
Congratulations to Alexandra Boegli for her very successful PhD defense 🎓
Congratulations to Doctor Alexandra Boegli who very successfully defended her PhD on Listeria activation of NLRP6 through induction of lysosomal damage 🥳!! Very well deserved (and a very well enjoyed celebration) 🥂
In March and April, we were pleased to welcome two new colleagues: postdoctoral researcher Rafik, and PhD student Alex. We’re excited to have them on board and look forward to the ideas and energy they’ll bring to the team.
New preprint from Abigail Strefeler and @jourdainlab!
🚨New preprint available! Third and final in the #CRISPR screen series!🚨 👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis biorxiv.org/content/10.110… By A. Strefeler in collaboration with @Pagliarini_Lab Please RT 🙏🏻 🧵1/9
🚀 Exciting opportunity! 🎓 The PhD program in Cancer and Immunology in Lausanne is accepting applications! If you're passionate about advancing research in cancer or immunology, we want to hear from you! 🌟 #PhD #CancerResearch #Immunology unil.ch/cancer-immunol… via @unil
This study from Bernaleau et al. @RebsamenLab @unil reveals CCDC134 as a central regulator of the chaperone Gp96, thereby controlling TLR biogenesis and responses. hubs.la/Q02_6cJz0 #InnateImmunity #inflammation
Check out the Insights piece from A Blumenthal & L Dominguez Cadena @Blumenthal_Lab on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis. Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs.
Insights: from Cadena & @Blumenthal_Lab @UQMedicine: @RebsamenLab (hubs.la/Q035qctm0) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96. hubs.la/Q035pXY50
Congrats to @EBernard1993 for winning the poster prize at the Swiss LS2 conference for his work on the activation mechanism of Ninj1 during cell death!! 🥳 @DIB_UNIL @LS2Switzerland
Postdoc position in the Jourdain Lab!
2 weeks left to apply to the postdoc position in our lab AND we are extending the call to 2 topics! ➡️ nucleotide metabolism in #immunometabolism and #cancer in vivo ➡️ mitochondrial RNA granules in #innate_immunity Same link: jourdainlab.org/wp-content/upl… @FBM_UNIL @mitojobs
New preprint from Marcell Harhai and @jourdainlab!
New preprint from the lab! 🚨 🧫 New galactose #CRISPR screening strategy 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂Mito defects in #Menieres disease by Marcell Harhai @FBM_UNIL A short thread 1/5 biorxiv.org/content/10.110…
New preprint from @AlexandraBoegli and @broz_lab !
Happy to announce the first preprint of my PhD 🥳 We show that the inflammasome receptor NLRP6 is activated by sterile or pathogen induced endolysosomal damage. Thanks to all the coauthors of the study @EBernard1993 and @broz_lab, including twitterless Louise, Gaël and Vanessa
New paper from @AlesDrobek and @RebsamenLab in @NatureComms!
Excited to share our latest paper out today in @NatureComms! Great work led by postdoc @AlesDrobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago. #innateimmunity #autoimmunity nature.com/articles/s4146…
Postdoc position available in the Jourdain Lab!
📢We're recruiting📢 Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo! Please share #uridine #cancermetabolism #immunometabolism @FBM_UNIL @unil 🔗(PDF): jourdainlab.org/wp-content/upl…
Funded postdoctoral position available in the Jourdain Lab!
📢We're recruiting📢 Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo! #uridine #cancermetabolism #immunometabolism @FBM_UNIL @FBM_UNIL @DIB_UNIL 🔗(PDF): jourdainlab.org/wp-content/upl…
New paper from @BernaleauL and @RebsamenLab in @JExpMed!
Very happy to share our latest work just published in @JExpMed! Our amazing PhD student @BernaleauL shows that CCDC134 controls TLR biogenesis through the ER-chaperone Gp96. rupress.org/jem/article/22…
New manuscript by Sina Bohnacker and @JuliaEsservB published in Science Immunology!
Decoding Worm Strategies to Advance Vaccines and Therapies 🧬 👉t1p.de/56h2i A study led by Prof. Julia Esser-von Bieren and Dr. Sina Bohnacker, #HelmholtzMunich, @TU_Muenchen, and @unil, reveals how worm parasites (#helminths) evade immune defenses by manipulating…
Hot off the press, check out our News & Views on recent work from @dixitvishva @IshanDeshpande showing how NINJ1 is held inactive in living cells. Free to read in @NatureNV rdcu.be/d2nqH
Did you know that NINJ1 exists as an autoinhibited dimer in the PM of cells? In a @NatureNV @EBernard1993 and Petr describe new results from @dixitvishva and @IshanDeshpande, including a resting structure of NINJ1 with 3 helices! Check it out here: rdcu.be/d2nqH
An excellent summary by @EBernard1993 and @broz_lab , contextualizing our recent work.
How is the protein NINJ1 regulated so that cells break open only when they die? go.nature.com/4eXszaJ