Collin Ewald
@CollinEwald
Research on diseases of aging and regenerative medicine @Novartis. Views are mine. #matreotype. VP of http://ssmb.ch,P of http://ssfar.ch
Thank you @VeraBohren for this wonderful portrait and interview at #69inspiringPeople. 69people.ch/en/people/dr-c…
We are seeking an #innovation-focused #postdoctoral researcher to develop and refine in-vitro protocols using #patient-derived #iPSCs for neuronal aging. novartis.com/careers/career…
I really liked the way Jan Gruber explained "biological aging" clocks at day 1 of @LongevityDublin. What should a useful clock be able to do? (1) Identify existing disease (2) Detect early, hidden and subclinical disease in an interpretable/explainable manner (3) Provide…
New brief on the Biology of Aging is out by the United Nations. Honored to be a Scientific Board Member. un.org/scientific-adv…
Targeting DNA damage in ageing: towards supercharging DNA repair, read now our latest article in @NaturePortfolio Nature Reviews in Drug Discovery. @ArBujarrabal @George_Garinis Paul Robbins Jan Vijg @CECAD_ @UKKoeln Free access to the article here: rdcu.be/eqK9r
New BSRA seminar incoming! On June 26 at 4pm UK time, we’re joined by Dr Della David (@BabrahamInst) for a deep dive into: “Strategies to Mitigate Age-Dependent Protein Aggregation” Free + open to anyone interested in ageing biology. bsra.org.uk/events/seminar…
Wonderful talk by @jangruber467 who was able to model a mystery from my former lab. If its all damage accumulation, how can the lifespan of C. elegans be doubled at the end of life? A physics derived model can explain it! youtu.be/pXFE_dcDIDc?si…
Exciting science on your end-of-year wish list?!? >> apply to our postdoc and PhD positions and start 2025 with a new job @UniBasel
Please RT: we have @snsf_ch -funded #Postdoc and #PhD positions in our lab, to investigate the gene regulatory dynamics during vertebrate skeletogenesis in a comparative setting (see doi.org/10.1101/2024.0… and doi.org/10.1101/2024.1… ) - apply by 31.12.24, start date by 1.2.25!
#ARDD2024 Collin Ewald at ARDD2024: Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age youtu.be/2APxO5Tr8Z4
Congrats to @peter_meister’ s lab. Condensin I folds C.elegans folds genomes. nature.com/articles/s4158…
Roles for matrix/basement membrane proteins nidogen and laminin in sensing touch. C. elegans touch receptor neurons direct mechanosensory complex organization via repurposing conserved basal lamina proteins sciencedirect.com/science/articl…
📢New Open🔓Access Article Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age by Adrian Molière & Collin Y. Ewald (@CollinEwald) et al. rdcu.be/dME0d #endoflife #frailty #insulin #IGF1 #longevity #proteinhomeostasis #resilience
How To Choose a Good Scientific Problem (1/3)
Quality of supplements targeting aging: Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim | GeroScience (springer.com)
Registration closes this Friday, 21 June! 📣 We are looking forward to welcoming you in #Mainz next week. ➡️ imb.de/dgfa2024 #alternsforschung #ageingresearch
1 more month to register for the "Annual Meeting of the German Association for #Aging Research". Taking place 27-28 June at IMB. ➡️ imb.de/dgfa2024 #alternsforschung #ageingresearch
This study raises the possibility that the effect of #IIS and related pathways on resilience and frailty during aging in higher animals might possess some degree of reversibility. @GeroScienceAGE 🍬🔬👵 @AdrianMoliere @CollinEwald et al. link.springer.com/article/10.100…
Kudos to @AdrianMoliere, @ParkisLaelaps, and the team for pushing this over the finish line. I'm so happy this work got published! It looks like end-of-life doubling of lifespan upon daf-2 degradation potentially via restoring #protein #homeostasis.
It’s never too late: Our new paper explores how auxin-mediated DAF-2 degradation still massively extends lifespan even at a very old age. A short 🧵 #Aging #GeroScience #AgingResearch link.springer.com/article/10.100…
Big thanks to @GeroScienceAGE, @CollinEwald, and all the collaborators for this amazing project: @ParkisLaelaps, @Anita, Elena M Vayndorf, Bruce Zhang, Kuei Ching Hsiung, Yoonji Jung, Sujeong Kwon, Cyril Statzer, @Meyer_DH, Richard Nguyen, Joseph Chadwick, @Max_t88