Donal O'Carroll
@CarrollDonal
RNA, epigenetics & the germline😀
Over the moon to finally share my PhD work with you 🎉 We found that the chromatin reader SPIN1 is essential in transposon control and ensure the precision of DNA methylation. It was such a joy working on it, I hope you enjoy the read! nature.com/articles/s4158…
Interested in piRNAs and transposon DNA methylation? Our new collaborative work revels a key mechanism underpinning the precision of piRNA-guided LINE1 methylation. Congratulation to all the authors! nature.com/articles/s4158…
Congratulations to @CarrollDonal who has been elected as a Fellow of the @RoyalSociety 🌟 His research has led to insights into fertility & the complex mechanisms that ensure genetic information is protected as it passes from one generation to the next ➡️edin.ac/43oQUmj
nature.com/articles/s4146… Delighted we could participate in this amazing study. It shows that the piRNA pathway is central to supporting human male fertility and transposon silencing .
Delighted to share our new work in @NatureCancer in collaboration with @SchofieldOxford led by @hannahjlawson & James Holt-Martyn. We found that HIF hydroxylases are potent therapeutic targets in AML. @ICR_London. nature.com/articles/s4301…. 1/4
Online Now: C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line dlvr.it/T2l9SR
Discovery of a pair of genes that work in perfect harmony to protect male fertility, could provide new insights into some unexplained cases of the most severe form of infertility Study by @CarrollDonal & @AnsgarZoch in @MolecularCell ➡️ edin.ac/4bwHpER
Interested in understanding the dynamics of hematopoietic homeostasis, take a look at our freshly published collaborative study: authors.elsevier.com/sd/article/S19… Well done to all the authors. It was fantastic to collaborate with the @BertieGottgens and @kamilkranc labs.
A great first day as a new Group Leader & Centre Director @ICR_London presenting our work on targeting mRNA modifications in AML at the Keystone RNA modifications symposium. Looking forward to setting up the new lab when I get back to London! #KSRNAMod24
Our best paper just came out. Fantastic collaboration w. Richard Stefl @CEITEC_Brno, @CZphenogenomics & @CarrollDonal, thanks to everyone involved. Congrats to @zamore_lab & @KorostelevLab on great D.m. Dicer-1 stuff in the same issue. miRNA Dicers differ! cell.com/molecular-cell…
Our #CRU326 member & #clinician #scientist @MargotWyrwoll was granted the @DFG_public 'Walter Benjamin Fellowship' for joining the lab of @CarrollDonal in Edinburgh. Here, she will be for working on piRNA-mediated #transposon silencing - what a great opportunity!
Training the next generation of Interdiciplinary Scientists. Applications for the 2023 Wellcome 4 year PhD programme in Integrated Cell Mechanisms (iCM) are now open! Join the next cohort on this innovative PhD Programme. For more info see wcb.ed.ac.uk/iCMPhD #phd #phdlife
A time and single-cell resolved model of hematopoiesis: tinyurl.com/2s3vhr8r. With @kamilkranc and @CarrollDonal groups, we have generated a new model of hematopoiesis, fit for the single cell genomics era, building on @fabian_theis group tinyurl.com/ywpxtrum. @SCICambridge
Great collaboration, a long project going as back as 2014. My lab with help of @CZphenogenomics at @imgprague & @CarrollDonal lab studied mutant mice and Richard Stefl's lab @CEITEC_Brno solved cryo-EM structures. Richard's not on Twitter but @K77Karel is.
Save the dates! "Noncoding RNAs in Development and Cell Differentiation" at the Weizmann Institute 30/1-2/2/2023. Co-organized with @OdedRechavi @LCochella @CarrollDonal. We promise great science 🧪, yummy food 🍢, and best-in-class weather in the winter☀️. Details to follow ...
The O’Carroll lab is looking for talented postdoctoral research associates to join us in our quest to explore piRNA-directed DNA methylation. elxw.fa.em3.oraclecloud.com/hcmUI/Candidat…
How do blood stem cells protect themselves from burnout whilst fighting an infection? @CarrollDonal study @JExpMed reveals YTHDF2 protein regulates inflammatory response… Prevents premature aging & allows production healthy blood cells throughout life edin.ac/36hXcGz
Delighted that our latest YTHDF2 paper is out! mRNA m6A and its reader YTHDF2 supress proinflammatory gene expression in haematopoietic stem cells to prevent exhaustion and premature ageing. doi.org/10.1084/jem.20…