Peter Dirks
@BrainSurgn1989
Pediatric neurosurgeon in Toronto. Loves working at SickKids. Trying to make young lives better through surgery and research.
Medicine is a lesser profession without a solid grounding in the humanities nytimes.com/2021/04/10/opi…
Two world-leading research teams in Australia and North America have shown a potential new targeted therapy for childhood brain cancer effectively kills tumour cells in pre-clinical models. @UofT @SickKidsNews @EmoryUniversity #braincancer #researchforgood #medicalresearch 🧵
Happy to share the “behind the paper” that @kinjaldesai156 and I wrote on our new paper @NatureComms, targeting cell fate transitions in medulloblastoma! Targeting proliferative activation of stem cells blocks tumor formation and regrowth after Rx. communities.springernature.com/posts/targetin…
Very pleased to post this new study from my group led by Kinjal Desai, targeting a rare cell fate OLIG2-mediated transition in the medullo hierarchy with CT-179. Preventing stem cell activation!#naturecomm can01.safelinks.protection.outlook.com/?url=https%3A%…
Nature research paper: Gliomagenesis mimics an injury response orchestrated by neural crest-like cells go.nature.com/3DF9uNP
Read our latest #research on glioblastoma origins and growth, injury-reprogramming to neural crest-like identity, led by Akram Hamed from my lab, with @lincolndstein,@MarioniLab,@BenSimons_Lab, published with @SpringerNature in @nature, rdcu.be/d5n7I
Recapitulating cerebellar granule neurogenesis Read this Research Highlight showcasing work from Biren Dave @birendave3, Peter Dirks @BrainSurgn1989 and colleagues @SKDevStemCell @SickKidsNews: journals.biologists.com/dev/article/15…
My first first-author manuscript is now on bioRxiv, thanks to everyone that helped put this together!
Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis biorxiv.org/cgi/content/sh… #bioRxiv
Congratulations to @BrainSurgn1989 and his team and the collaborators!
Very pleased to share our latest paper led by PhD student Akram Hamed and great collab with Ben Simons (U Cambridge) and Lincoln Stein(OICR)! Single cell neural stem cell maps and brain tumor insights! nature.com/articles/s4146…
Very pleased to share our latest paper led by PhD student Akram Hamed and great collab with Ben Simons (U Cambridge) and Lincoln Stein(OICR)! Single cell neural stem cell maps and brain tumor insights! nature.com/articles/s4146…
Wishing best of luck to these six outstanding incoming R1s, Eagan, Aaron, Jas, Patrick, Jessica and Mary, as they start their #neurosurgery journey @UofTNeuroSurge. @gelarehzadeh @Sunnybrook @UnityHealthTO @UHN @SickKidsNews
What determines recognition in science? The good fortune to work with dozens of outstanding trainees, research associates, and international colleagues who collectively help build durable scientific stories that stand the test of time #Reproducibility Science is done by teams
#InternationalChildhoodCancerDay Recognizing all the great work being done for high risk childhood cancer @SickKidsNews by @drmeredithirwin @Uri_Tabori @vijayvijay1979, @JamesRutka @BrainSurgn1989 @WBderry David Malkin, CGuidos, JDanska JHitzler
@cancersociety Highlighting the important research of @DrAnnieHuang on the genetics of rare pediatric brain tumors - leading to new therapies -on #InternationalChildhoodCancerDay @RBTCSickKids @SickKidsNews @uoftmedicine @SickKidsCancer #WomenInScience 🎗️👇
Researchers from SickKids, @pmcancercentre, @uoftmedicine led by Dr. Peter Dirks (pictured in his lab pre-pandemic) have found a promising new approach to stop growth of #braincancer cells. Published today in @NatureComms. Read more: bit.ly/2LIs0Km
Out today! our study of PRMT5 inhibitors in GBM disrupt splicing, cell cycle and stemness. Awesome collaboration with @BrainSurgn1989, @thesgconline, @katlinbm, @bhaibeka @MatLupien, and many others @SU2C_Canada Cancer Stem Cell Dream Team. rdcu.be/cfaDG
PRMT5 inhibition disrupts splicing and stemness in glioblastoma | Nature Comm. New paper from our @SU2C @su2c_canada team! Great work with @cherylarrowsm1 @thesgconline @RockyMtnBrain @bhaibeka @MatLupien nature.com/articles/s4146…
Another publication from the lab and @bhaibeka, showing how #epigenetics informs of the genetic architecture of potency from stem to mature cells: Large organized chromatin lysine domains help distinguish primitive from differentiated cell populations disq.us/t/3ubzxex
New work from our @SU2C team. GSC states also defined by chromatin openness, including an aggressive invasive type not seen in other data. Led by @MatLupien & Paul Guilhamon w @StephAngers @marcoUofC @RockyMtnBrain @bhaibeka @MollyShoichet, Mike Taylor. elifesciences.org/articles/64090
Thanks to @BrainSurgn1989 @StephAngers @marcoUofC @RockyMtnBrain @bhaibeka @MollyShoichet, Mike Taylor the #SU2C brain cancer dream team and all others involved.
Another good news from the lab to start 2021: latest publication - chromatin accessibility and glioblastoma cancer #stemcell. More than genetics & heterogeneity in CSC across primary tumours where one CSC subtype linked to worst outcome. doi.org/10.7554/eLife.… @eLife