Bingxu Liu
@BingxuL
Postdoc @UW IPD David Baker group. PhD @mit bio, Darrell Irvine lab and Nir Hacohen lab.
And you can see Nathan's post for more details of the work.
Imagine teaching immune cells to precisely target diseased cells and ignore healthy ones. 🎯 Using deep learning, we’ve designed de novo proteins that can distinguish small differences on the surface of cells through MHC molecules. This work is out now in @ScienceMagazine! 🧵
Thank you for the support, Shiyu!
Congrats to @UWproteindesign @BingxuL and other teams on an impressive trio of papers advancing MHC binder design. science.org/doi/10.1126/sc…
In January 2026, I will be joining Berkeley @UCBerkeley as an Assistant Professor in the Department of Chemical and Biomolecular Engineering, College of Chemistry @UCB_Chemistry, with exciting connections with world-class communities including the Lawrence Berkeley National…
Chatting with Bo about random interesting topics by the coffee machine is one of my greatest memories during the last year of grad school.
Meet Bo Xia, a systems biologist using both AI tools and experimental technologies to understand how the genome controls cell fate in health and disease. Learn about Bo in a #WhyIScience Q&A: broad.io/WISBo
So pleased to share that the Executive Committee of MIT has approved the promotion of Bryan Bryson to Associate Professor with Tenure.
New enzymes can unlock chemistry we never had access to before. Here, we introduce RFdiffusion2 (RFD2), a generative model that makes significant strides in de novo enzyme design. Preprint: biorxiv.org/content/10.110… Code: coming soon Animation credit: x.com/ichaydon (1/n)
Huge congrats to all the awardees, especially @dawnchenx @RomanBarth2 @tongzhang1109
A huge congratulations to the recipients of the 2025 Weintraub Award! These ten exceptional graduate students exemplify the bold, creative, and pioneering spirit embodied by Dr. Hal Weintraub. fredhutch.org/en/news/releas…
Excited and proud to have this paper published with @NatureComms today! Great project led by @DrJuanLMendoza at @UChicagoPME and @HHMINEWS. Excited for the future of the field - stay tuned for a full breakdown and walkthrough of our results! nature.com/articles/s4146…
This really remind me of the scene from "Your Name"
Starship exploding captured on an airplane
Will be in Hawaii for Winter QBio from 2/15-2/20, would love to learn cool new subjects from new friends. DM me if you are also around and want to chat(or surf together)!
Gentili et al. performed genome-wide optical pooled CRISPR screens to identify genes regulating trafficking and signaling of the innate immune sensor STING. @broadinstitute @mgentili_ @BlaineyLab cell.com/cell-systems/f…
Sun and Brown preview “Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening” @SinaiGenetics cell.com/cell-systems/f…
De novo binders for pMHC-1 complexes I particularly like this work because it answers two questions I often have about de novo binders: 1) Does this unlock a new set of targets? 2) Why can't we just use antibodies? pMHC-1 is a key target class that we're just starting to crack…
Can we use deep learning models to specifically target cancer cells? In our new preprint from the Baker lab we report how we can design fully de novo TCR mimics to distinguish antigenic peptides from “self” peptides on MHC class I and activate T cells biorxiv.org/content/10.110…
same with Boston
You can drive for 149 hours across Russia and still be in Russia
amazing, great to see this out~
Our paper on continuous mutagenesis in living cells using HACE is now out in @ScienceMagazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…