Ben Strober
@BennyStrobes
Postdoctoral researcher with Alkes Price at Harvard School of Public Health. Genetic regulation, probabilistic modeling, and some rock climbing.
Cool new framework to link variants to their target genes!
pgBoost, led by @elizabethdorans , is now out in @NatureGenet : highlights the utility of genetic effects on gene expression (eQTLs) to benchmark and unify multiome peak-gene links and genomic distance. nature.com/articles/s4158…
Thousands of GWAS hits—but how do we link them to biology? 🚨New from Alkes Price group: J-PEP integrates pleiotropy and epigenomic data to reveal shared disease mechanisms across diseases surl.li/gtzlnr #genomics #Statistics @HarvardChanSPH
“No government—regardless of which party is in power—should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue.” - President Alan Garber hrvd.me/GarberRespond3…
Announcing a new preprint from my lab from my talented grad student Ziqi Xu! We created scGeneHE (pronounced sc-genie) to fully leverage single cell RNAseq data in the estimation of genetic heritability of gene expression. biorxiv.org/content/10.110…
📣Excited to share my last postdoc paper with @soumya_boston on eQTL mechanisms depending on where the RNA is in the cell! @BrighamResearch @broadinstitute TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵👇
Early and late RNA eQTL are driven by different genetic mechanisms biorxiv.org/content/10.110… #biorxiv_genomic
Massive new eQTL and sQTL resource from the TOPMed consortium🧬 👉14,324 ancestrally diverse samples (WGS & RNAseq) 👉6 tissue/cell types 👉saturation of eGenes (cis-eQTLs for 88% of genes) 👉no saturation of secondary cis- or trans-eQTL detection 👉69,766 and 35,770 cis-eQTL…
My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. It’s available on Amazon: tinyurl.com/mx2hewen
Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students will find it useful! I’ll share updates soon