Ayşegül Erdem

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells go.nature.com/3ItTXms

New preprint from our lab! Given the importance of nucleotide synthesis for AML cells, and the fact that aspartate is essential for nucleotide synthesis, we wondered if exogenous aspartate uptake through EAAT transporters plays a role in this cancer.

New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10.11…

Interested in stem cell and cancer research? 🔬 🧫 🧪 We are still looking for a lab technician to join our team in Brussels (Belgium)! 👩‍🔬 👨🏽‍🔬 We’ll consider any career level, only requirement is that you have experience working with mice! 🐁 Start date: asap!

We have put together an amazing line-up of invited speakers and talks selected from abstracts for the 2nd Annual ISEH Mini-Symposium!!! Join us online on March 26th (free for ISEH members) to learn what’s new and exciting in Experimental Hematology!!! @ISEHSociety

New preprint from our lab! @deDuveInstitute @UCLouvain_ADRE @WELRI_asbl Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival biorxiv.org/content/10.110…

We are still looking for a lab technician with experience in mouse experiments! Apply to join our dynamic team and contribute to better understanding of blood development and leukemia! 🩸🐁

I am 🥳 and so thankful to @K_B_Foundation for the prestigious initiave grant award 🏆 to study the #metabolic crosstalk in leukemic bone marrow🩸🧪🔬 Huge special thanks to @nickvangastel @deDuveInstitute 🌟📚and also to @The_Ito_Lab @Einstein_SCI to all our collaborators🌟💙

Two posters from our lab at #ISEH2024 today: @hernan_tiradoc presents his work on GOT enzymes as metabolic vulnerability in AML (nr 3234), and I present work from @Nithya029 and @Aysglrdm on how protein S-acylation allows metabolic flexibility in AML (nr 3004)! @ISEHSociety

nature.com/articles/s4158… Excited to share new work form our lab led by Shinya Imada and Saleh Kwaled @KhawaledSaleh demonstrating how a post-fast refeeding drives stem cell mediated regeneration via polyamine metabolites. The work would not have been possible without our great…

I'm very excited to share the first original research paper of the lab, out now in Experimental Hematology! @ISEHSociety @deDuveInstitute @UCLouvain_be @WELRI_asbl Optimization of pre-enrichment strategies for mouse hematopoietic stem... sciencedirect.com/science/articl…

Online now our review paper highlighting the role of NADPH in HSC!!

Excited to share our latest review on the roles of the mitochondrial NADPH-cholesterol axis in supporting extracellular vesicle (EV) biogenesis for hematopoietic homeostasis. It's now online @TrendsCellBio!! @Cla_Morganti @Einstein_SCI @MassimoBONORA1 bit.ly/3Wmd055

Huge comgratulations Ayşegül @Aysglrdm and Nick @nickvangastel!!

So happy to be awarded with the prestigious FNRS grant for our ongoing project⭐️ 📊 Thank you @nickvangastel @deDuveInstitute and @frsFNRS 🥳🥳🥳

Thank you so much @ghotamis hocam, for today’s wonderful meeting at @gshlab_ulkerctr 🥳🥳🤩

Vacancy: research technician to study LSC-niche interactions