Zach Walsh

Thrilled to share the latest work from my PhD in the @BizarMd group! This has been a dream MD/PhD project, culminating in data that has already enabled access to precision therapy for a patient. Tweetorial below:

We validated screen results and phenotypes using T cells from two APDS patients with variants mapping to structural GOF hotspots flagged by our screen, directly linking screen data to real disease.

Had a wonderful experience presenting our work developing a scalable variant classification approach for inborn errors of immunity at @JointMeeting @the_asci @A_P_S_A last week! And very grateful to have received a travel award to support my attendance.

For this week’s #MRFResearchWednesday, we’re spotlighting 2025 Medical Student Grant Awardee @Zwalsh96 of @ColumbiaMed, working in the Izar Lab, with @BizarMd. His project, “Leveraging T Cell Genetic Variants to Enhance Melanoma Immunotherapies,” explores new ways to improve…

Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment: Cell cell.com/cell/fulltext/… Thrilled to see this transformative paper published- and so sad that its NIH funds are frozen!

Great to see our work featured by @ColumbiaMed! New Method Speeds Diagnosis of Rare Genetic Disease cuimc.columbia.edu/news/new-metho…

Now online! Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment dlvr.it/TLT5Xf

Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment @CellCellPress @BizarMd @joshuamilner2 @FrangiehChris @zwalsh96 cell.com/cell/fulltext/…

Excited to be presenting more of our scalable variant classification work tomorrow at @ImmunologyAAI #IMMUNOLOGY2025. Check it out if you are interested in #CRISPR base editing, forward genetic screening, or immunogenetics! My talk starts at 8:45 AM tomorrow (May 5) in Room 312!

Very excited to have received the notice of award for my F30 MD/PhD fellowship from the NCI today! Much thanks to my mentor @BizarMd and excited to continue our work at the nexus of cell therapy and genome engineering

Happy to share our manuscript “Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases” published in @NatureMedicine. Congrats @lcaprio412. Thank you @BizarMd. nature.com/articles/s4159…

🗓️Join us TODAY! March 4th *⃣ Zachary Walsh (@zwalsh96 , @ColumbiaMed) on scalable #Crispr screens for variant effects in T cells. *⃣Malvika Tejura & Shawn Fayer (@ShawnFayerGC , @uwgenome) on improving #VariantEffectPredictor s for clinical use. varianteffect.org/seminar-series

Congratulations to @lcaprio412 @SomnathTagore, many people in my group, and outstanding collaborators @DenisSchapiro @KresBestak @insitubiology @carisls and many others on this paper, profiling non-small cell lung cancer brain metastases nature.com/articles/s4159…

Very excited to be presenting on March 4! If you are interested in T cell engineering, immunotherapies, or studying variant effects, check it out -- more info below

Huge congratulations to my good friend and former Fry lab labmate @KoleDeGolier on his beautiful paper published in Nature Immunology!

Today we report in @NatureGenet the genetic landscape of cancer drug resistance mechanisms from CRISPR base editing screens nature.com/articles/s4158…

Pleased to share that our recently published work on CRISPR base editing in primary human T cells has been featured in @nyphospital Advances! Check out this article, where my mentor @BizarMd and I were interviewed about our work: nyp.org/advances/artic…

Thrilled, and also in a bit of disbelief, to see our paper featured on the cover of @ScienceMagazine! "Finding Neo" wasn't easy, but we just kept swimming (read: stared at a sequence of DNA) until the Eureka moment hit.