Structural Genomics Consortium (SGC)

Also in this month's issue is an update on Target 2035 from @CherylArrowsmi1, Stefan Knapp and colleagues covering the efforts of the EUbOPEN project which is contributing to the goals of #Target2035💡 Read the #OpenAccess article here⬇ pubs.rsc.org/en/content/art…

The AIRCHECK Workshop isn't just another conference! It is an exclusive opportunity to learn, experiment, and get ahead of the curve in ML/AI-driven hit discovery. Register now: event.fourwaves.com/aircheckworksh…

We are uniting experts in ML, computational chemistry, and drug discovery to get hands-on experience with AIRCHECK. Co-developed by SGC and @UHN, AIRCHECK is an open data platform designed to enhance predictive models in drug discovery. Register here: event.fourwaves.com/aircheckworksh…

A rigorous study of UPS tool compounds for #degrader evaluation is published by Stefan Knapp @thesgconline in ACS Chemical Biology! They determine the appropriate doses of UPS pathway inhibitors that robustly rescue degradation without displaying off-target activity and toxicity.

Researchers at @thesgconline and The Neuro, along with scientists from 11 major antibody manufacturers, have developed and standardized an #OpenScience platform to characterize research antibodies. @YCharOS1 aims to tackle a critical challenge in biomedical research…

We co-hosted " @target2035 – A Public-Private Partnership to Accelerate Hit-Finding" along with @ucl and @pfizer. 50 leaders from the pharmaceutical industry, academia, and funding organizations discussed how AI and ML can transform drug discovery. thesgc.org/news/structura…

#MAINFRAME is launching! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery. Join us: aircheck.ai/mainframe

We just launched #MAINFRAME! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery. Join us: aircheck.ai/mainframe

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein pubs.acs.org/doi/10.1021/ac… @CherylArrowsmi1 @ian_dunn_ @aledmedwards @friedo91 @fgentile9 @olexandr @spiwokv @MKCMU @Sumera_Perveen @janhjensen @mattschap #JCIM Vol64 Issue22 #compchem

Supported by @UofTDSI, a program led by @mattschap will provide trainees with the skills necessary to interpret complex experimental data and drive breakthroughs in drug discovery. Registration for the first 9-week bootcamp is now open. thesgc.org/news/sgc-launc…

New episode for our Target 2035 Podcast Series 🎧 @MilkaKostic talks with @aledmedwards to unpack his journey from a traditional research scientist to a passionate open science advocate. Listen here: bit.ly/3AZQkBm

A summary of the efforts of @EUbOPEN, a public-private partnership dedicated to create, distribute and annotate the largest openly available set of high-quality chemical modulators for human proteins. pubs.rsc.org/en/content/art…

We have joined the Bluesky community! Follow us to stay updated on our latest research, collaborations, and efforts to shape the future of drug discovery. bsky.app/profile/thesgc…

How does EZH2 inhibition make atypical teratoid rhabdoid tumor cells vulnerable to therapy? A collaborative study using UNC1999, a high-quality chemical probe developed through a collaboration between the SGC @UNCPharmacy. nature.com/articles/s4146…

We report four DCAF1-based PROTACs with endogenous and exogenous WDR5 degradation effects and high-resolution crystal structures of the ternary complexes of DCAF1-PROTAC-WDR5. nature.com/articles/s4146… #PROTACs #DCAF1 #WDR #DrugDiscovery #OpenScience

A comprehensive study that offers validated ligands for future autophagosome tethering compound (ATTEC) development and advances targeted protein degradation strategies. nature.com/articles/s4146…

A 2024 update on @Chemical_probes highlights a significant expansion in the number of chemical probes and human protein targets, along with major improvements in expert review processes and user engagement. academic.oup.com/nar/advance-ar…

A fully open framework for DEL-ML hit discovery. We replace explicit DEL compound structures with ML-ready chemical fingerprints, enabling the broad scientific community to advance DEL-ML models and refine discovery methods. All data available on AIRCHECK. chemrxiv.org/engage/chemrxi…

A well anticipated overview highlighting the first CACHE challenge, which brought together 23 research teams from 10 countries to collectively predict 1,955 compounds targeting LRRK2-a protein linked to #ParkinsonsDisease. pubs.acs.org/doi/10.1021/ac…

🚨 New publication alert! 🚨 Our latest update on the Chemical Probes Portal is live! 🎉 📜 Read the paper: doi.org/10.1093/nar/gk… 🔍 Learn about our expanded content + improved functionality in the 2024 Nucleic Acids Research Database Issue. #ChemicalProbes #BiomedicalResearch