Chrysothemis Brown
@themis_brown
Physician Scientist @MSKCancerCenter Pediatrician | Immunologist @chrysothemisbrown.bsky.social
Very happy to share our study describing a new lineage of RORgt+ antigen presenting cells – Thetis cells – that instruct Treg differentiation and tolerance to gut microbes during early life! nature.com/articles/s4158… Brilliant teamwork led by @BlossomAkagbosu and @ZTayyebi 🧵 1/
#Immunology out now @ScienceMagazine After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. buff.ly/lCPsea3 By Jobinet al.
Enormously grateful to @psscra for their support which will allow us to embark on studies of Thetis cells in colorectal cancer, a wonderful collaboration with @KarunaGaneshLab!
Please join us in celebrating the 2025 Pershing Square Sohn Cancer Prize winners! This year’s six scientists have been selected for their bold ideas and potential to transform cancer research. The winners are: pershingsquarephilanthropies.org/news/the-persh…
Very cool study @KevinYTChen @SantoshVardhana !!
#Preprint alert! @KevinYTChen, a brilliant @GSKGradSchool graduate student and NCI F99/K00 awardee, identifies a novel, post-transcriptional checkpoint on intratumoral T cell function: biorxiv.org/content/10.110…
🚨Today in @Nature, we show that mRNA mis-splicing creates clonal public neoantigens in solid cancers. An amazing collaboration between @UCSFCancer and @MSKCancerCenter driven by @DarwinKwok1 and co-led by Hideho Okada, @josephcostell14 and @KlebanoffLab. nature.com/articles/s4158…