Snijder Lab

We are beyond proud of our newest @NatureMedicine paper! Using pharmacoscopy & in-silico drug MoA discovery, we show that the antidepressant Vortioxietine is effective in #Glioblastoma primary patient material and in mouse models. bit.ly/GBM_SL   #PersonalizedMedicine

Please welcome HT SpaceM, our new method for high-throughput small-molecule single-cell metabolomics: 👉Delafiori, Shahraz et al, BioRxiv biorxiv.org/content/10.110… 🧵👇

A single-cell ex vivo screening of repurposable drugs in #glioblastoma coupled with machine learning show that anti-tumour neuroactive drugs converge on the AP1-BTG pathway and identify the antidepressant vortioxetine as a potential therapeutic agent. nature.com/articles/s4159…

Researchers at ETH Zurich have used a drug screening platform they developed to show that an #Antidepressant, currently on the market, kills #Tumour cells in the dreaded #Glioblastoma – at least in the cell-culture dish. brnw.ch/21wMV3Q

We are happy to announce that the PHRT-funded clinical study “RAPID 01”, which includes patients with acute myeloid leukemia (AML) is moving into the next phase: Soon, the first patient will be recruited. Read more about it here: bit.ly/3XLDbnU

This beautiful image illustrates our new paper on 13C-SpaceM, a new method tracing metabolic activity in single cells in @NatMetabolism 😁 First, about the paper nature.com/articles/s4225… 📜:

🦓 This week: 'stripy' #Tcells! A recent @ScienceMagazine article from Dr. Ben Hale and a team in Dr. @BerendSnijder's lab suggests that T cell architecture is a key determinant of TCR signaling & #CellFate. @SnijderLab 📑: bit.ly/45A25ZR 🎤: bit.ly/3VXX1vr

Researchers identify key differences in inner workings of immune cells: more than half of all killer T cells exhibit nuclear invaginations, or folds in the cell’s nuclear envelope. brnw.ch/21wKwHr

#Tweetorial for our paper in @ScienceMagazine It's still largely unknown how naïve T cells decide to become either effector or memory T cells during viral infection. We show that these decisions are built into the cellular architecture of our T cells. 1/9 bit.ly/stripyBH

Looking forward to talking about #StripyTcells and our recent @ScienceMagazine publication with @thalexandrov, his team, and you (if you want)! The talk is public, so feel free to join: embl-org.zoom.us/j/94431042602?… Big thanks to Theodore & co. for the invitation!