Simona Cristea
@simocristea
cancer genomics AI scientist; head of Data Science & AI and group leader @DanaFarber_Hale; research scientist @Harvard; phd @eth.🇷🇴🇸🇪🇨🇭🇺🇸
scRNAseq cell type annotation is notoriously messy. Despite so many algorithms, most researchers still rely on manual annotations using marker genes In a new preprint accepted at ICML GenAI Bio Workshop, we ask if reasoning LLMs (DeepSeek-R1) can help with cell type annotation🧵

RL scaling is meant to hit a wall in real-world tasks because such tasks are designed to be done by many people together & include lots of redundancies & inefficiencies. anybody who worked among many people knows that it’s seldom the “best” (by a clear metric) solution that wins.
extremely excited to share my lab's research of AI for cancer genomics at the neurIPS 2025 workshop on multi-modal foundation models in san diego
We are excited to organize NeurIPS 2025 2nd Workshop on Multi-modal Foundation Models and Large Language Models for Life Sciences. The workshop features a stellar lineup of invited speakers, including Ziv Bar-Joseph, Charlotte Bunne @_bunnech , Simona Cristea @simocristea ,…
This R packages can transform any plot using color pallets from painting at the Museum of Modern Art in New York github.com/BlakeRMills/Me…




I disagree with lots of what François (used to) say, but I think he's super right here
In order to supervise an automation tool (or another person!) effectively, you need to be able to do the same job yourself. Doesn't matter if you rarely ever do the job yourself (like a manager who no longer codes), you need to be *able* to do it.
computational biology/bio ML has changed more in the past 2 years than in the last 10. “i have experience with CNNs for images, can I get an AI research job” doesn’t work anymore. if you’re trying to solve a pure prediction problem, you need to constantly know SOTA AI methodology
I might get this wrong, but why on Earth do people use chatGPT to generate “in-depth” blog posts on a technical topic? Doesn’t this literally beat the purpose? Like what is the point, what value does this bring to this world, what can one learn/gain from this? I don’t get this