Scott Isaacs
@scottisaacsmd
President @theaace, endocrinologist, obesity medicine, #MASLD, Emory Med School adjunct faculty. Posts are my own.
Metabolic disease rates are increasing in East Asia. A new review in @NatRevGastroHep shows the rise is driven by rapid lifestyle shifts and the adoption of Westernized diets, combined with genetics. East Asian populations are especially susceptible at lower BMIs.…
Steatotic liver disease is common in older adults (33.3% prevalence), but it’s more a marker of multimorbidity & low physical activity, not underlying cirrhosis. 2.4% had significant fibrosis. nature.com/articles/s4435…
Cost-effectiveness of tirzepatide vs lifestyle modification for overweight & obesity. Tirzepatide provided more QALYs but at higher costs, with cost-effectiveness ratios below $150k/QALY. onlinelibrary.wiley.com/doi/full/10.10…
Potential downsides of calorie restriction: While it may extend lifespan and reduce age-related diseases, it can delay wound healing, increase hunger & cold sensitivity, reduce bone density, shrink organs including the brain, impair reproduction, and impact immunity. Negative…
The BMI is a marker of total body mass and not a specific marker of adipose tissue mass. Relative fat mass #RFM is an alternative to BMI with superior performance of RFM in assessing cardiometabolic risk. nature.com/articles/s4157…
New study in primary care T2D patients: 🔍 59% had #MASLD ⚠️ 7% showed signs of advanced fibrosis ⚖️ Obesity increased risk of fibrotic MASLD by 8x 💔 MASLD linked to CV changes & ectopic fat 📌 Screening needed in diabetic primary care onlinelibrary.wiley.com/doi/10.1111/jo…
59% of patients with type 2 diabetes in primary care clinics have MASLD, 7% have advanced fibrosis (transient elastography ≥ 10 kPa), and 1.9% have cirrhosis. onlinelibrary.wiley.com/doi/10.1111/jo…
New study finds kids with #MASLD are more likely to have subclinical hypothyroidism, even after accounting for obesity and other factors. Higher TSH linked to worse liver outcomes. journals.lww.com/hep/citation/2…
A call for doubling the diagnostic rate of at-risk metabolic dysfunction-associated steatohepatitis @JVLazarus @TheLancet @geneyim @AlkhouriNaim pubmed.ncbi.nlm.nih.gov/40672054/
Ultraprocessed foods now make up 2/3 of U.S. calories and are linked to obesity, diabetes, cardiovascular disease & more. Time for stronger policies: taxes, warning labels, healthier school meals, and marketing limits. nejm.org/doi/full/10.10…
Tirzepatide improves metabolic hypogonadism better than transdermal testosterone according to this study presented at #ENDO2025. Always happy to give my comments for MedCentral. medcentral.com/endocrinology/…
Both GIPR agonism and antagonism reduce body weight and food intake but operate through fundamentally distinct neural pathways. GIPR agonism functions independently of GLP-1R signaling, relying on GABAergic neurons in the central nervous system to exert its effects. In contrast,…
New in @NatureMetabolism: Estradiol isn’t just about reproduction, estrogen regulates metabolism in both women and men. E2 and its receptors shape metabolic health, and E2 replacement may help reduce metabolic disease risk after menopause. nature.com/articles/s4225…
A new review in @NatureRevEndo on adipose tissue in metabolic health and ageing. Adipose tissue undergoes early and dynamic remodeling, especially in visceral fat depots which can trigger systemic metabolic decline. Age-related changes in adipose tissue are not uniform; different…
Just wrapped two amazing conferences back-to-back. First in Querétaro, Mexico 🇲🇽 for the National Hepatology Congress, then straight to San Francisco 🇺🇸 for #ENDO2025. Exhausted but deeply grateful for the rewarding experience of reconnecting with brilliant colleagues and friends…
A new study on the long-term impact of bile acid changes after bariatric surgery on type 2 diabetes outcomes, looking beyond just weight loss. While total bile acid levels increased in the first year after surgery, they returned to baseline by year five. Principal component…
Great to see my friend @DrJayyy__ at #ENDO2025
One of the best things about #ENDO2025 is reuniting with colleagues and friends across the country! @scottisaacsmd
Thrilled to be at #ENDO2025 in San Francisco for @askdrfatima’s plenary, “Changing the Game of Obesity Care Across Lifespan: Policies, Diets, and Drug Innovation.” Her insights on the future of obesity treatment are truly inspiring.
It was a privilege to help @andreapetersen as she explored her journey with continuous glucose monitoring for @WSJ. Fluctuations in glucose levels are a normal part life, and using a #CGM can provide meaningful insights into how the foods you eat impact your body. @TheAACE…
The SURMOUNT-MMO trial is underway to test if #tirzepatide can reduce heart attacks, strokes, heart failure, and death in adults with obesity. This global study will enroll ~15,000 people at risk for cardiovascular events and is the first trial to see if an incretin medication…
