Roger S. McIntyre, MD, FRCPC

Esketamine NS has a meaningful effect on improving measures of anhedonia in a real world sample of persons living with difficult to treat depression. An important and timely report from Giacomo d’Andrea and my friends and colleagues in Italy. sciencedirect.com/science/articl…

Results challenge notion that acute restoration of GABA and glutamate is essential for SSRI ECT TMS Ketamine efficacy provide tentative evidence supporting a role for composite Glutamate- Glutamine Glx among responders implicates astrocyte dysregulation sciencedirect.com/science/articl…

Interesting new study demonstrating that intranasally delivered insulin targets 11 critical areas in the brain subserving psychopathology across neuro degenerative and other mental disorders alz-journals.onlinelibrary.wiley.com/doi/10.1002/tr…

Summary and synthesis by my colleagues in China and Singapore of potential biomarkers to diagnose bipolar disorder authors.elsevier.com/c/1lT~9_4ssaX5…

It’s great to see that’s zuranalone (Zurzuvae) is now available for women with postpartum depression nytimes.com/2025/07/22/hea…

A man with bipolar disorder experiencing psychotic manic episodes celebrated by effusive commentary by ChatGPT: a version of AI sycophancy. Aspects around AI-guided illness management have opportunities and risks in psychiatry wsj.com/tech/ai/chatgp… pubmed.ncbi.nlm.nih.gov/40220270/

The FDA advisory committee has recommended against the approval of brexpiprazole in combination with sertraline for the treatment of PTSD by a vote of 10-1 The FDA has not set an action date for final decision reuters.com/business/healt…

Lumateperone effective in both bipolar I and bipolar II depression. Congrats to my colleagues in Italy leading this synthesis pubmed.ncbi.nlm.nih.gov/40659186/

Improvement in quality of life and functioning in adults with treatment-resistant depression (TRD) independent of improvement of depressive symptoms. Congrats to Charles Conway and team on this interesting analysis! pubmed.ncbi.nlm.nih.gov/40657595/

Esketamine and ketamine associate with lower reporting most aspects of suicidality to the WHO Pharmacovigilance database Thanks to Angela Kwan from my research team in leading this report pubmed.ncbi.nlm.nih.gov/40637548/

Interesting report on antidepressant discontinuation syndrome …agree the mood exacerbation likely reflects underlying mood disorder pubmed.ncbi.nlm.nih.gov/40632531/

Exercise improves cognition, in addition cognitive functions influence probability of exercise in bipolar disorder, probably reflects interdigitation with reward function and motivation. Congrats to my colleague on Australia this very nice study pubmed.ncbi.nlm.nih.gov/40611430/

A very nice study conducted by colleagues in Hong Kong led by Doctor Heidi Lo evaluating with ecological momentary assessment EMA in real time, reward based disturbances in persons with depression and bipolar disorder. Very interesting data. cambridge.org/core/journals/…

A history of GLP1 and GIP back to Pavlov synthesis of the past 150 years that provided the intriguing possibility that incretins are not only integral to normal brain function but also the pathophysiology prevention and treatment of mental illness psychiatrictimes.com/view/incretins

Very promising results for mebufotenin 5 MEO DMT in treatment, resistant depression, the most impressive results to this point in the serotonin psychedelic space ir.atai.com/news-releases/…

Telehealth originated prescription of stimulants for ADHD does not increase the risk of substance use disorder but may increase risk of stimulant use disorder pubmed.ncbi.nlm.nih.gov/40495525/

GLP-1 Receptor Agonists (GLP-1 RAs; e.g., Ozempic) are consequential therapeutics for psychiatric disorders. I describe how they could be transformational in psychiatry targeting current medical conditions and possibly treating psychiatric disorders cdn.sanity.io/files/0vv8moc6…

One of the most clever studies I’ve seen in quite some time! Activating the immune system worsens Anhedonia in adults with depression who also have elevated CRP ie > 3mg/l…. implicates an inflammatory subtype pubmed.ncbi.nlm.nih.gov/40264292/

APESAC group …. Persons who are currently adults who experienced teratogenic effects from prenatal exposure to valproic acid (valproate)…reported 53% of their children (n = 187) had major congenital malformations …..suggest transgenerational risk cambridge.org/core/product/i…

Increase in inflammatory markers during Covid-19 increases risk of depression, especially suicidality Accords with the inflammatory hypothesis of psychiatric illness very nice work by my friends in Columbia pubmed.ncbi.nlm.nih.gov/40548319/