Robert Castelo

A simple ingestible pill innovation for monitoring inflammation of the gut cell.com/device/fulltex…

Science finally retracts the Arsenic life paper science.org/content/articl…

🚂Els usuaris freqüents de tren tenen més símptomes d’ansietat, depressió i malestar físic que la mitjana de la població. Són les primeres conclusions d’un estudi #URV que ha analitzat si la crisi ferroviària afecta el benestar emocional dels usuaris. 👉diaridigital.urv.cat/usuaris-tren-s…

You solidify understanding by teaching it to someone else.

New online! An evolutionary continuum between non-coding and coding DNA bit.ly/4m6Kz6F

Are you worried about your DNA revealing too much about you? The @washingtonpost says you should be very worried. I have a different take: stevensalzberg.substack.com/p/i-know-genom…

Interesting: nature.com/articles/d4158… - low quality papers linking some seemingly random phenotypes eg in UKBiobank, "flooding" the literature. Exploring all possible combinatorial possibilities of phenotype combinations sounds like a science business model now...

Excited to share a milestone published in @NatureMedicine from our decade-long effort to build The Human Phenotype Project, a unique longitudinal cohort with unmatched depth of clinical and multi-omic profiling, enabling truly predictive, personalized medicine. Led together with…

Preprint on "Finding easy regions for short-read variant calling from pangenome data": arxiv.org/abs/2507.03718

The evolution of allostery in a protein family. New preprint from the brilliant @ainamartiaranda. Seven complete allosteric maps. biorxiv.org/content/10.110…

How gut inflammation can induce brain inflammation nature.com/articles/s4158… @Nature

Cancer vaccines will be a big part of the future of immunotherapy. A new, super review @TheLancet thelancet.com/journals/lance…

What if SCALE is a solved problem? 🤔 Sequencing-Free Single-Cell Genomics with STAMP! 💣 Now published in @CellCellPress: Our approach for scalable, cost-effective analysis of millions of single cells or hundreds of samples—without sequencing. By replacing sequencing with…

Like a fine wine, this work has taken some years to mature—but it's finally time to pop the cork!🍾 Our open-access article is now out in @EMBOJournal: "Genetic polymorphisms lead to major, locus-specific, variation in piRNA production in mouse" embopress.org/doi/full/10.10… 🧵👇

BREAKING: MIT just completed the first brain scan study of ChatGPT users & the results are terrifying. Turns out, AI isn't making us more productive. It's making us cognitively bankrupt. Here's what 4 months of data revealed: (hint: we've been measuring productivity all wrong)

“Springer Nature Portfolio has launched a “Discover” series of journals that seem to deliberately and systematically mimic the MDPI brand.” …in-on-scientific-publishing.github.io/website/posts/…

Preprint on "Improving spliced alignment by modeling splice sites with deep learning". It describes minisplice for modeling splice signals. Minimap2 and miniprot now optionally use the predicted scores to improve spliced alignment. arxiv.org/abs/2506.12986

I’m very happy to share our latest ABRF - Genomics ResearchGroup study “The impact of PCR duplication on RNAseq data generated using NovaSeq 6000, NovaSeq X, AVITI, and G4 sequencers,” is now published in Genome Biology! genomebiology.biomedcentral.com/articles/10.11…

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature. This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at @CRGenomica nature.com/articles/s4158…

I'm happy to present our new web-tool CORESH alserglab.wustl.edu/coresh/ for searching public gene expression datasets using gene signature as a query, developed by @vd_sukhov, which was just published in @NAR_open doi.org/10.1093/nar/gk… 1/n