Laura Chacon Machado
@pomarros4
Microbiology PhD candidate at @Cornell @JoePetersLab Interested in bacterial genetics, MGEs are my favorites 🧬✨
Our preprint is now published science.org/doi/10.1126/sc…
Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear genomes. We identified several families of independently evolved telomeric transposons. 1/7 biorxiv.org/content/10.110…
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their…
Recent work from the lab from Laura Chacon @pomarros4 describing a family of Tn7-like transposons that evolved to target CRISPR repeats being presented at #cshlTE24 and now on bioRxiv biorxiv.org/content/10.110…
A family of Tn7-like transposons evolved to target CRISPR repeats biorxiv.org/cgi/content/sh… #biorxiv_molbio
It was a pleasure working with @PopoMicro on this review of CRISPR-Cas associated transposons (CAST). Hopefully it gives a sense for the diversity of Tn7-like transposons and CRISPR systems that independently combined.go.shr.lc/444PwFh
This story involved many hands over many years led by @BertCorrea3 and @SaadleeS. Novel mechanisms of diversity generation in Acinetobacter baumannii resistance islands driven by Tn7-like elements academic.oup.com/nar/article/do…