Pablo Alcón
@palconh
Scientist @MolBiolAU. From Extremadura, Spain. 🧬🔬
Our latest work on FANCD2-FANCI (D2-I), a complex that helps resolve DNA crosslinks and replication stress, is out! nature.com/articles/s4158… We show D2-I acts as a sliding clamp on DNA, stalling at single-stranded gaps to identify and protect damage sites. @lapassmore @RuedaLab

I'll soon be recruiting a postdoc fellow to join us @ MRC LMB to continue developing our programme to understand neuroimmune modulation 🧠🔬🧬🩸🫁 If you're interested in joining us check also @MSCActions, @wellcometrust & www2.mrc-lmb.cam.ac.uk/recruitment/ri… & DM'me youtu.be/-oEXpyjWBFU?si…
Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @SanchoLab, se acaba de publicar en la revista @Nature 👇 elpais.com/salud-y-bienes…
If neuroimmunology and/or pain signalling are your things 💥, and you are looking for a PhD position 👨🎓👩🎓, check the post below! 👇 There is still time to apply for a PhD position in my lab and carry out your doctoral thesis on this exciting topic🔬🧪 More details below 👇
Want to do a PhD and are passionate about neuroimmunology? Curious about the crosstalk between mast cells and pain-sensing neurons? A position is now open in my lab—apply now! Details here👇 in.umh-csic.es/en/ofertas/phd… Feel free to contact me for more info—and please spread the word
A tribute to Pedro Cuatrecasas, the Spaniard who (whilst working in the US) co-invented affinity chromatography.
Es difícil que una persona al azar no se haya beneficiado del descomunal trabajo del prácticamente desconocido científico Pedro Cuatrecasas. Participó en el desarrollo de unos 40 medicamentos, como el aciclovir, el sumatriptán y la atorvastatina elpais.com/ciencia/2025-0…
Es difícil que una persona al azar no se haya beneficiado del descomunal trabajo del prácticamente desconocido científico Pedro Cuatrecasas. Participó en el desarrollo de unos 40 medicamentos, como el aciclovir, el sumatriptán y la atorvastatina elpais.com/ciencia/2025-0…
Si no conseguistes un contrato FPU 2025, pero sigues interesado en realizar una tesis doctoral, contacta con nosotros para solicitar un contrato del Plan Propio de Investigación de la U. Sevilla. Unete a nosotros!! tvirtual.us.es/teous-rest-api…
📢 We’re hiring! Looking for a lab technician (FP level) with experience in cloning, protein expression & purification. 🧬 Join our structural & molecular biology lab @CIB_CSIC 🗓️ 2-year contract, starts Oct 2025 📩 Apply by July 31 👇
Want to do a PhD and are passionate about neuroimmunology? Curious about the crosstalk between mast cells and pain-sensing neurons? A position is now open in my lab—apply now! Details here👇 in.umh-csic.es/en/ofertas/phd… Feel free to contact me for more info—and please spread the word
Researchers learned a function of enzyme MORC2, that helps organise DNA and turn off genes when not needed. Mutations in MORC2 cause Charcot-Marie-Tooth disease, a rare condition that weakens muscles. These findings could lead to new treatments. nature.com/articles/s4146… 🧵1/2
Happy and proud of this study where we propose that cross-reactivity between dietary and airborne antigens with molecular mimicry might play a role in explaining the concomitant appearance of in IBS and allergic rhinitis @BoeckxstaensLab @TARGID_KULEUVEN
🆕🔥⬆️#AllergicRhinitis in #IBS patients & has a detrimental effect on #QoL‼️ 🎯Potential cross-reactivity between #Dietary & #Airborne antigens in patients with concomitant IBS & AR👏 👉onlinelibrary.wiley.com/doi/10.1111/nm… @BoeckxstaensLab @Javimmunopain @TARGID_KULEUVEN @ANMSociety @esnm_eu
✅ Hoy celebramos el acto institucional del 2️⃣5️⃣ aniversario del @ciccancer de #Salamanca. Este vídeo está dedicado a todas las personas que trabajan en él para derrotar al cáncer. @usal @CSIC @ASEICAnews @ContraCancerEs @criscancer
✅ Quieres hacer un máster especifícame dirigido al cáncer a nivel básico y clínico❓ 👉El @ciccancer te ofrece esta oportunidad en la @usal 📅 Plazo de preinscripción: del 3 de abril al 18 de julio de 2025. ➕Info: guias.usal.es/node/203568
Si te interesa descubrir cómo las máquinas macromoleculares controlan la transmisión de información genética usando criomicroscopía electrónica, ¡consulta nuestro programa (JAEINT24_EX_0109) y contáctanos! 🧬🔬 #JAEIntro2025 @JAEIntro_CSIC @CIB_CSIC
🎺 Ayer se publicó en el @boegob la convocatoria JAE Intro 2025 y HOY comienza el plazo de solicitudes ❕ 🔛 Becas de introducción a la investigación para estudiantes universitari@s #JAEIntro25 ℹ️ Encuentra toda la información en 👉 sede.csic.gob.es/tramites/progr… 🗓️ Hasta el 2 de mayo
Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances science.org/doi/10.1126/sc…
Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. cell.com/molecular-cell…
This is going to be an amazing meeting, great opportunity to show your latest research. We will select quite a few talks from abstracts, don't forget to submit yours!
🔴⚠Next CNIO-@CaixaResearch Frontiers Meetings: Machines acting on DNA and RNA, a molecular mechanistic perspective. 📆May 28-30th 👥Organizers: @LlorcaLab, @rfleiro and @NogalesLab. 🔗More info and registrations: cnio.es/eventos/machin…
Now online! Following our work in @Nature (go.nature.com/3bLDkQN), we now publish in @AGA_Gastro that psychological stress can disrupt the development of oral tolerance to dietary antigens and lead to IgE-mediated and mast cell-induced visceral pain upon antigen ingestion
📢 New research in @AGA_Gastro 📢 Psychological stress-induced local immune response to food antigens increases pain signaling across the gut in mice shorturl.at/Cjju8 Congrats to the 1st authors @Javimmunopain Cintya and Josue 👏 #DGBI #GITwitter #IBS
Casi un centenar de profesores del Claustro de Doctores de la Universidad de Salamanca acaba de votar en contra de conceder un honoris causa a don Rafael Nadal Parera (177 a favor, 91 en contra). El voto a favor de Charpentier, ganadora del Nobel, ha sido prácticamente unánime.
Postdoc position available: Discover new IFT cargoes using AI methods. international.au.dk/about/profile/…
There is nothing like seeing an article online!
Chromokinesin KIF4A activation of human condensin I involves a SLiM interfering with auto-inhibitory intramolecular interactions within condensin, exemplifying a conserved mechanism for regulating diverse SMC complexes @cutts_dr, Luis Aragon et al embopress.org/doi/full/10.10…