Miriam Lisci
@miriamlisci
@EMBO postdoc fellow @jourdainlab @DIB_UNIL diving into immunometabolism | Previously @griffiths_lab @theCIMR @Cambridge_Uni and @RutgersU.
Could you live without glutamine? I am delighted to share our preprint @jourdainlab: we employed parallel nutrient and genetic screeening to tackle the mechanisms promoting survival in glutamine-limiting conditions. Check it out 👇 more details below! biorxiv.org/content/10.110…
Pint of Science was again a great success in Lausanne, with >500 people attending our events! Kudos to co-coordinators @miriamlisci and @JSLuneau, and to the fantastic team of 19 volunteers at the bars 🥳! #PINT25 #scicomm
📷 Looking for #volunteers for the 2025 #Swiss edition of the Pint of Science Festival, an international event focused on making science accessible and engaging for all. 🎉 Join #PINT25 Check our website and bellow!
The latest pre-print from the lab is out! 🥳 In this work led by our PhD student Abigail, the @jourdainlab adds a piece to the puzzle of mechanisms balancing #pyrimidines and #purine synthesis, and hints at #NUDT5 expression as a potential predictor of chemotherapy resistance.
🚨New preprint available! Third and final in the #CRISPR screen series!🚨 👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis biorxiv.org/content/10.110… By A. Strefeler in collaboration with @Pagliarini_Lab Please RT 🙏🏻 🧵1/9
Postdoc position in the Jourdain Lab!
2 weeks left to apply to the postdoc position in our lab AND we are extending the call to 2 topics! ➡️ nucleotide metabolism in #immunometabolism and #cancer in vivo ➡️ mitochondrial RNA granules in #innate_immunity Same link: jourdainlab.org/wp-content/upl… @FBM_UNIL @mitojobs
2 weeks left to apply to the postdoc position in our lab AND we are extending the call to 2 topics! ➡️ nucleotide metabolism in #immunometabolism and #cancer in vivo ➡️ mitochondrial RNA granules in #innate_immunity Same link: jourdainlab.org/wp-content/upl… @FBM_UNIL @mitojobs
Check out our new pre-print from the @jourdainlab ! How do growth and death screens compare when uncovering novel regulators of mitochondrial function? Is Ménière disease a mitochondrial disorder? Find out below 👇
New preprint from the lab! 🚨 🧫 New galactose #CRISPR screening strategy 🎯 481 genes required for #OXPHOS ⚙️ #FAM136A in IMS proteostasis 👂Mito defects in #Menieres disease by Marcell Harhai @FBM_UNIL A short thread 1/5 biorxiv.org/content/10.110…
I’m happy to share the latest work from my postdoc, just published in @NatureComms! We show for the first time in vivo the critical involvement of SLC15A4/TASL complex in endosomal TLR immune responses through IRF5 activation. nature.com/articles/s4146… #innateimmunity #autoimmunity
🚨Why can’t mammals regenerate legs or arms like frog tadpoles or salamanders? Our preprint tackles (part of) this BIG question with surprising findings about oxygen sensing 🔗biorxiv.org/content/10.110… Happy New Year, everyone! 🎉 🐭 vs 🐸 #evodevo #regenerative #cellbio 🧵👇
📢We're recruiting📢 Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo! Please share #uridine #cancermetabolism #immunometabolism @FBM_UNIL @unil 🔗(PDF): jourdainlab.org/wp-content/upl…
Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024.1…), and @sturm_gav et al. dissect the biophysics behind it (doi.org/10.1101/2024.1…). Details below! 🔬🧵
🎉Excited to announce job openings in our new lab at @MPI_Bio /FML in Tübingen!🇩🇪Looking for enthusiastic colleagues to explore regeneration together! We have positions for: 🔬Research Technician 💻Bioinformatician 🎓PhD studentship 🧪🔬📖 Postdoc Details and links below👇
📢We're recruiting📢 Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo! #uridine #cancermetabolism #immunometabolism @FBM_UNIL @FBM_UNIL @DIB_UNIL 🔗(PDF): jourdainlab.org/wp-content/upl…
An image from postdoc Emeline Recazens on the cover of PNAS! This picture highlights the recent @jourdainlab @DIB_UNIL publication led by M. Foged on the role of mitochondrial RNA granules in innate immunity.
Stressed mitochondrial RNA granules from our recent work on the cover of @PNASNews! A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1. #mitochondria #dsRNA @FBM_UNIL
New paper 🚨 from @jourdainlab Fresh off the press on @PNASNews!
Our story on a novel pathway that controls #mitochondria from the 𝐜𝐲𝐭𝐨𝐬𝐨𝐥 and influences #immunity is now peer-reviewed and available at @PNASNews! pnas.org/doi/10.1073/pn… By M. Foged @DIB_UNIL @FBM_UNIL @MuenchLab @VamsiMootha #N6AMT1 #mtDNA #RNA_processing A recap 🧵
I am very happy to share the first results from my postdoc in the @broz_lab. We investigated how the plasma membrane gets ruptured during #celldeath and discovered that cell swelling endows #NINJ1 filaments with the ability to induce rupture.
The lab's latest NINJ1 story is out on @biorxivpreprint 🥳 Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling biorxiv.org/content/10.110…
The direct link to our recent pre-print FBXW7 alleviates c-MYC repression of pyruvate carboxylase to support metabolic flexibility biorxiv.org/content/10.110…