Mikhail Tikhonov
@mikhtikh
Theoretical physicist thinking about ecology and evolution. Of microbes, and spheres in vacuum.
We developed an experiment to increase the scale of QTL mapping so that we may observe how 'low effect' variants play a role in determining phenotypes. 1/4
Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast biorxiv.org/cgi/content/sh… #biorxiv_genetic
Excited to share the fruit of a collaboration with the @SeppeKuehnLab and Madhav Mani, just out in Nature. Driven by the powerhouse duo of @kiseokmicro and Siqi Liu. Predictable functional regimes in minimally processed soil + a simple model recapitulates functional dynamics!
Published in Nature today! Here, we sought to systematically ask how natural community's metabolism changes with the environment. A simple consumer-resource model can predict N cycle metabolism and, more importantly, the mechanism behind its change. nature.com/articles/s4158…
Excited to share the fruit of a collaboration with the fantastic @SeppeKuehnLab and Madhav Mani, driven by the powerhouse duo of @kiseokmicro and Siqi Liu. Predictable functional phases in minimally processed soil + a simple model recapitulates functional dynamics!
Published in Nature today! Here, we sought to systematically ask how natural community's metabolism changes with the environment. A simple consumer-resource model can predict N cycle metabolism and, more importantly, the mechanism behind its change. nature.com/articles/s4158…
A fantastic collaboration and what a pleasure to be spending my sabbatical with @SeppeKuehnLab at @UChicago. Now we just need to understand *why* this works!
Published in Nature today! Here, we sought to systematically ask how natural community's metabolism changes with the environment. A simple consumer-resource model can predict N cycle metabolism and, more importantly, the mechanism behind its change. nature.com/articles/s4158…
Excited to share that our coarse-graining paper is out in Physical Review X! Highlights in the thread below. go.aps.org/3MiFCWM
1/4 Excited to share our new work! Coarse-grained descriptions of ecology clearly work (@asanchez_lab), but the strains they group together can behave very differently indeed (@oxcordero). How do we reconcile the paradox? biorxiv.org/content/10.110…