CL • Le Cong
@lecong
Building AI4Science Foundation Models and AI Agents for Biomedicine, Accelerating the Engineering of Life, on Earth, on Mars, and Beyond!
🤔 How do you get an LLM to reason like a CRISPR pro—or any top scientist? By training it on real expert conversations. 🛠️ What we built • An automated pipeline that distills learning signals from 10 + years of genomics discussions • Genome-Bench: 3,000 + curated Q&As on…

💔 2nd&3rd deaths linked to Sarepta gene therapy—trial pause, stock drop. Must accelerate safer gene & cell cures. AI design & AI agents + real world validation can help contribute! 🚀 AI momentum: SynBioBeta’s “Towards an AI-Driven CRISPR Future” (synbiobeta.com/read/towards-a…) charts…

Amazing Organizing Team: @MengdiWang10 @lecong, Alvaro @amritsinghbedi3 @ZaixiZhang Ruofan @SOURADIPCHAKR18 Jigang Zhenghong @avinashreddydev
🚨 Can AI design harmful viruses or toxic molecules? 🚨 🔥 At #NeurIPS2025, we’re launching a new workshop: 🔬 Biosecurity Safeguards for Generative AI Link : biosafe-gen-ai.github.io 🙏 Grateful to our amazing co-organizers and expert advisors! #BioSafeGenAI #AI4Science
📢 New frontier in AI4Science: What if AI could design novel pathogenic/toxic proteins & molecules? This raises urgent biosecurity questions. We're tackling this head-on at our #NeurIPS2025 Workshop on AI Biosecurity: biosafe-gen-ai.github.io AI foundation models trained on…
Perhaps we need more Soham-for-Bio, more AI, more data/benchmark, more multi-tasking, more trials/errors, instead of thinking we’ve hit “the wall”. I do not even see the “wall”. #SohamParekh #ai #drugdesign #bio #science #more
Our collaborative work, #RNAGenesis, led by @ZaixiZhang and team, delivers a Generalist RNA Foundation Model (full weights released!), end-to-end pipeline that understand, design, validate functional RNAs—from nM affinity aptamers to CRISPR scaffolds that lift editing efficiency…
🚀 Introducing 𝗥𝗡𝗔𝗚𝗲𝗻𝗲𝘀𝗶𝘀 — a 𝗚𝗲𝗻𝗲𝗿𝗮𝗹𝗶𝘀𝘁 𝗙𝗼𝘂𝗻𝗱𝗮𝘁𝗶𝗼𝗻 𝗺𝗼𝗱𝗲𝗹 for 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗡𝗔 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰𝘀, unifying sequence understanding, de novo design, and 3D structure prediction. From 𝗔𝗽𝘁𝗮𝗺𝗲𝗿𝘀 to 𝗚𝗲𝗻𝗲 𝗘𝗱𝗶𝘁𝗶𝗻𝗴,…
🚨 Introducing FoldMark — a generalist watermark framework to fortify protein generative AI against biosecurity threats 🧬 Why It Matters: • AI‑designed proteins could enable novel pathogens (e.g., SARS‑CoV‑2 variants), posing dual‑use risks arxiv.org/abs/2505.23839 •…
🚀 Introducing 𝗥𝗡𝗔𝗚𝗲𝗻𝗲𝘀𝗶𝘀 — a 𝗚𝗲𝗻𝗲𝗿𝗮𝗹𝗶𝘀𝘁 𝗙𝗼𝘂𝗻𝗱𝗮𝘁𝗶𝗼𝗻 𝗺𝗼𝗱𝗲𝗹 for 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗡𝗔 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰𝘀, unifying sequence understanding, de novo design, and 3D structure prediction. From 𝗔𝗽𝘁𝗮𝗺𝗲𝗿𝘀 to 𝗚𝗲𝗻𝗲 𝗘𝗱𝗶𝘁𝗶𝗻𝗴,…
Thrilled to host Dr. John Jumper of @GoogleDeepMind at Stanford today for a special seminar on #AlphaFold and the future of AI-powered biology—co-organised with my brilliant colleague @anshulkundaje. Amazing to watch #AI and #Genomics converge! #Stanford #DeepMind


💔 Shocked, saddened by the strike that damaged labs at the @WeizmannScience . Having attended Single-Cell-Genomics meeting organized by Ido Amit and my mentor Aviv Regev, I experienced an amazing campus filled with pursuit of knowledge, science, and freedom. @bitonslab…
🤔 How do you train an AI model to think and reason like a biology expert? We found the answer: let it learn from real expert discussions! Checkout our recent work on a breakthrough approach to improve LLM scientific reasoning - by learning directly from 10+ years of genomics…
A grant of nearly $10 million was announced May 28 to fund a Princeton-led effort using AI to develop advanced semiconductors for wireless communication and remote sensing. The effort will be directed by @EPrinceton prof @KSG_Princeton Read more: bit.ly/3FoaXt9
Announcing Biomni — the first general-purpose biomedical AI agent. Biomni is a free web platform where biomedical scientists can immediately delegate their tasks to Biomni, starting today! Biomni automates literature reviews, hypothesis generation, protocol design,…
The GAIA game is over, and Alita is the final answer. Alita takes the top spot in GAIA, outperforming OpenAI Deep Research and Manus. Many general-purpose agents rely heavily on large-scale, manually predefined tools and workflows. However, we believe that for general AI…