Child Lab
@laboratorychild
Chemical Microbiology, Drug discovery, Host-pathogen interactions, Target prioritization, buzz words, hyphenated techniques
What is happening? Something new... come join us jobs.ac.uk/enhanced/linki… @imperialcollege @QMUL @emblebi

Was excited to hear this story at ToxoCon, and it is great to see Toxo again being used for proteomic method development - worth a read - check it out 👇
Excited to share, in its final form, the work of Alice Herneisen mapping the #calcium responsive proteome of #Toxoplasma. doi.org/10.7554/eLife.… @eLife 1/4
Last opportunity to get involved - more details on the project can be found here laboratorychild.com/rare-disease
What is happening? Something new... come join us jobs.ac.uk/enhanced/linki… @imperialcollege @QMUL @emblebi
What's happening? Well, this happened - many congratulations to the freshly minted Dr. Wincott of barcoding fame (the delighted smiling face of success serves as the identifier in the image below) @ceirej @henrybenns @GrechJanessa @RossWaller3 @ImperialSci

Like shining a light into black boxes? Wondering if allostery could be the answer to all of your PhD dreams? If that sounds like you, come join us @ImperialLifeSci for an @icbcdt chembio #PhD with @TateScience @lwalport + Profs Yaliraki+Barahona @impchemistry @ImperialMaths 👌👇
📢 6 NEW studentships for October 2023 entry to the Imperial ICB CDT are now available! 📢 More details on Find a PhD 👇 findaphd.com/phds/institute… @impchemistry #AcademicTwitter
What a nice Christmas pressie! Our article highlighted by @mbogyo - hopefully help more people get to grips with functional PTM signatures and in-cell large scale parallel mutagenesis - it’s the gift that keeps giving @henrybenns @TateScience @TrendsParasitol @NatureMicrobiol
Dr @mbogyo highlights @TateScience & Matthew Child’s recent @NatureMicrobiol article on a drug discovery method combining #chemoproteomic profiling & #CRISPR-based gene editing. #Toxoplasma #Plasmodium #Cysteine @StanfordMed @impchemistry @ImperialLifeSci authors.elsevier.com/a/1gH-K5Eb1xBg…
I challenge any of my colleagues to show me any of their work from (at least) the past 10 years that did not in some way make use of data from VEuPathDB. Our science would be worse without it. Time to show some appreciation. Please vote for this immeasurably impactful resource 👇
Exciting news! #VEuPathDB is one of 20 finalists #DataWorks! Prize, for excellence in data sharing & reuse. Help your favorite competitor now by casting your vote for the People’s Choice Award by Dec 21 @Iamherox 🎦Watch: youtu.be/zUtmAldooq8 🗳️Vote: herox.com/dataworks
Delighted to have @ceirej 's hard work recognized and highlighted in @TrendsParasitol - an excellent analysis of our within-host population dynamics study from Dr Koshy @uarizona - another fab outcome of our collab with the wonderful @ewald_lab
Dr Anita A. Koshy highlights recent @CellRepMethods article from @ewald_lab, Matthew Child & colleagues on cellular #barcode revealing #Toxoplasma #gondii population dynamics within host. @UAZBIO5 @uarizona @MedicineUVA @UVA @imperialcollege authors.elsevier.com/a/1fzi05Eb1xBg…
Excited to announce CORe, proteome-wide in-cell site-directed mutagenesis screening @NatureMicrobiol! Deconvolute role of any ligandable site, reactive amino acid, PTM, and more, at scale, at endogenous abundance! Fantastic collaboration with @laboratorychild @henrybenns
Out now, drug discovery for apicomplexans👉CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery @laboratorychild @henrybenns @TateScience @imperialcollege nature.com/articles/s4156…
What he said 👇
Out now, drug discovery for apicomplexans👉CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery @laboratorychild @henrybenns @TateScience @imperialcollege nature.com/articles/s4156…
Great to have this out in print - and for @henrybenns hard work and the contributions of all our collaborators to be recognized. We’ve established our proteome engineering technology - now the fun of the application! Many thanks to @wellcometrust for believing in our science.
Out now, drug discovery for apicomplexans👉CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery @laboratorychild @henrybenns @TateScience @imperialcollege nature.com/articles/s4156…
CysDB: A Human Cysteine Database based on Experimental Quantitative Chemoproteomics [@Keribackus] dlvr.it/SZ24sb
More excellent research from our early career researchers. Céire Wincott @ceirej and @laboratorychild present a method for cellularly barcoding Toxoplasma parasites enabling the behaviour of up of 96 individual parasites to be tracked during infection. cell.com/cell-reports-m…
Our initial foray into within-host population genetics for Toxoplasma is out @CellRepMethods - congratulations @ceirej and many thanks to our wonderful collaborators @ewald_lab @Tiengwe_Lab @FrickelLab @MRC_LMS and funders @NC3Rs @wellcometrust @royalsociety @imperialcollege ...
A big week - the release of the first Child lab graduate out into the world. I'd say snap @henrybenns up, but @Novartis already have! Another Childling departs from the nest, making room for another - last chance to apply! imperial.ac.uk/jobs/descripti…
Our initial foray into within-host population genetics for Toxoplasma is out @CellRepMethods - congratulations @ceirej and many thanks to our wonderful collaborators @ewald_lab @Tiengwe_Lab @FrickelLab @MRC_LMS and funders @NC3Rs @wellcometrust @royalsociety @imperialcollege ...
After a night with coyotes in Joshua Tree, and a scientifically inspiring ToxoCon2022 in Riverside, it's fun to announce a post-doc position in our lab - interested in using proteome engineering to dissect entire PTM signaling networks in Toxo? Join us! nature.com/naturecareers/…
