Peter Kjer-Hansen
@kjer_peter
PhD candidate @GarvanInstitute in @Neuro_RNA lab. Interested in all things RNA, although especially alternative splicing and the protein diversity this enables!
Splice up your life! Excited to share our new Review on the potential of thinking protein isoforms when it comes to therapeutics! Link: rdcu.be/dSXxy Written with @Neuro_RNA @LabPhan A short overview🧵
Protein isoform-centric therapeutics: expanding targets and increasing specificity tinyurl.com/2v5c3us8 Many genes encode multiple protein isoforms. This new review discusses targeting isoforms as a route to drugs with greater specificity and fewer adverse effects
Online Now: Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer dlvr.it/TLbM4N
Thrilled to share my 1st PhD paper, exploring the role of a DAAM1 microexon in memory formation and learning! 🧠🐭💻🔬 #PhD #PhDthesis Finally published in @NatureComms: nature.com/articles/s4146… . With @mirimiam, @maradierssen, @Blencowe_Lab, @CRGenomica, @icerca Details below:
Protein isoform-centric therapeutics: expanding targets and increasing specificity: nature.com/articles/s4157…
The job call is officially open. If you're interested, please apply through this link ASAP! 😃 mdc-berlin.de/career/jobs/po… Please RT! 🙏
🚨🚨🚨 If you're a bioinformatician who loves: 🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing 🚀 Collaborating and travelling Apply to work with us at the spectacular @BIMSB_MDC in Berlin + @UPFbiomed-@CRGenomica in Barcelona. Qs:transdevolab.com Please RT!🙏
🐟Our new paper "Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish" is out in @eLife🐟 A nearly 10-year tour-de-force by Laura Lopez-Blanch and many others in the lab @CRGenomica & @UPFbiomed elifesciences.org/reviewed-prepr… Thread👇
Finally out nature.com/articles/s4158… the study (led by @xsalvatella1 & @RMendezLab) with the biophysical explanation for the profound effect of the microexon of CPEB4 as cause of autism, that we previously reported back in 2018 @ParrasAlbert @GeschwindLab @mirimiam @hervas_millan
The last part of my PhD research 🤓 is out!! If you are interested in RNA Biology -> Alternative Splicing and Epitranscriptomics + Evolution go have a look! A thread 🧵
The conserved landscape of RNA modifications and transcript diversity across mammalian evolution biorxiv.org/cgi/content/sh… #biorxiv_genomic
🚨🚨🚨 Very excited to share our new preprint on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4: biorxiv.org/cgi/content/sh… Work led by @SoBonnal, with Simon Bajew & @rmartinezcorral. @UPFbiomed, @CRGenomica. @ERC_Research. Short teaser👇1/7
Excited to share our new review discussing potential of targeting isoforms as a new route to drugs with greater specificity and fewer adverse effects! nature.com/articles/s4157… Published in @NatRevDrugDisc Congrats @kjer_peter @GarvanInstitute @UNSWBABS @EMBLAustralia
Protein isoform-centric therapeutics: expanding targets and increasing specificity tinyurl.com/2v5c3us8 Many genes encode multiple protein isoforms. This new review discusses targeting isoforms as a route to drugs with greater specificity and fewer adverse effects