Jakob Seidlitz

❗️NEW PREPRINT❗️ Brain size varies ~2-fold across adults, ~100 fold across primates, and nonlinearly changes across the lifespan. How is this reflected at the molecular level? biorxiv.org/content/10.110… Thread👇

⚡️New #preprint alert ⚡️ We show that #brain aberrations are highly heterogeneous after #preterm birth, and that there are consistent biological mechanisms and social environmental influences shaping these aberrations. 📰 Read the full preprint here: biorxiv.org/cgi/content/sh…

Multimodal data from 98 individuals: neuroimaging, genetics, dendritic spine morphometry, proteomics, and gene expression; identifies 100s of proteins that explain individual differences in MRI measures | Nature Neuroscience nature.com/articles/s4159…

Multimodal data from 98 individuals: neuroimaging, genetics, dendritic spine morphometry, proteomics, and gene expression; identifies 100s of proteins that explain individual differences in MRI measures @HerskowitzLab nature.com/articles/s4159…

It was such a special experience to see this groundbreaking paper in the making. The paper examines, among other things, ante-mortem functional connectivity and post-mortem omics ⭐️in the same people⭐️. Chockfull of wonders -- big congrats to @herkowitzlab and the whole team!

🧠 our new/expanded brain charts from >138,000 people‼️Gargantuan effort with @lenadorfschmidt @Aaron_A_B @rai_bethlehem

Charting structural brain asymmetry across the human lifespan biorxiv.org/content/10.110… #biorxiv_neursci

Comparing Brain-Behavior Relationships Across Dimensional, Tail-Sampled, and Propensity-Matched Models biorxiv.org/content/10.110… #biorxiv_neursci

How can we increase the replicability of brain-wide association studies in a rigorous way? A @Nature paper by @kaidikangkk @jakob_seidlitz @rai_bethlehem @sattertt @VandyAtVandy et al identifies the relevant study design features that contribute nature.com/articles/s4158…

Absolutely delighted to see our review of structural MRI brain similarity networks out! The culmination of months of exciting conversations with co-first author @isaac_sebenius and the stellar team of @Aaron_A_B, @jakob_seidlitz, @Sarah_Morgan_UK and Ed Bullmore!

Structural MRI of brain similarity networks — a Review by Isaac Sebenius, Lena Dorfschmidt, Jakob Seidlitz, Aaron Alexander-Bloch, Sarah E. Morgan & Edward Bullmore go.nature.com/3D6tMiF @isaac_sebenius @lenadorfschmidt @jakob_seidlitz @Aaron_A_B @Sarah_Morgan_UK

✨Our paper, published in @Nature today, investigated how we can leverage study designs to improve the replicability of brain-wide association studies (BWAS). nature.com/articles/s4158…

Our recent publication and open source release of a de-identification tool to protect patient privacy while empowering #openscience of brain MRIs. Great collaborating with @BenjaminKannMD @Aaron_A_B @jakob_seidlitz and their teams! @ChildrensPhila @PennMedicine @DanaFarber

Great study by @garedaba @StuartJoldham @jakob_seidlitz and colleagues, linking molecular and anatomical descriptions of the prenatal brain, now out in @NatureComms: Molecular signatures of cortical expansion in the human foetal brain 🧠🧬 nature.com/articles/s4146…

Wooo! Awesome new work from Kevin Sun integrating personalized functional networks, genomic risk, and clinical psychopathology!!

How are genetic risk for mental illness, personalized functional brain networks, and overall psychopathology related during early adolescence? New preprint out now medrxiv.org/content/10.110… and I'll be presenting a poster at #Flux2024 this Sunday! (1/17)

Curious about human brain development through an animal model? 🧠🐒Check out our new preprint on Brain Charts of the Rhesus Macaque Lifespan! We've mapped normative trajectories for macaque brains using 1.5k MRI scans from PRIME-DE and collaborators! biorxiv.org/content/10.110…

Can lifespan brain charts from rhesus macaques inform our understanding of neurodevelopment across species? A new preprint by @TingsterX et al. presents detailed MRI-based normative trajectories for brain structure, based on 1,522 scans. Check it out here: biorxiv.org/content/10.110…

Our paper is now out in Neuron! @NeuroCellPress (details from preprint thread below, now with more results and containerized pipeline!) w/ @bogglerapture @edbullmore @petra_vertes and amazing coauthors cell.com/neuron/fulltex…

Thrilled to share our preprint introducing ComBatLS, a new data harmonization method that preserves covariates’ (e.g. age and sex) effects on variance! (1/2) biorxiv.org/content/10.110…

Assessing CT-based Volumetric Analysis via Transfer Learning with MRI and Manual Labels for Idiopathic Normal Pressure Hydrocephalus medrxiv.org/cgi/content/sh… #medRxiv