Journal of Allergy and Clinical Immunology

An Editors’ Choice paper’s data suggest that local T cells in the nasal cavity can produce IL-26. This IL-26 reflects bronchoalveolar pathology and clinical symptoms and may offer an accessible target for clinically relevant endotyping of COPD. bit.ly/4nReCkv

Endotyping holds increasing importance in allergy and immunology, and a steadily growing wealth of omics data on allergic conditions has spurred interest in multi-omic approaches for endotype discovery. Learn more in a Paradigms and perspectives piece. bit.ly/40lKgMZ

Accurate chronic rhinosinusitis (CRS) endotyping increases available therapeutic strategies and enhances clinical management. Read about the novel mechanisms associated with different CRS endotypes and new endotype-driven biologic treatments here. bit.ly/4ko5GA3

TNF-ɑ can be targeted to treat diseases like rheumatoid arthritis and psoriasis, and the targeted therapies can also induce inflammatory conditions as an adverse reaction. Does TNF-ɑ protect from skin inflammation, and what are the underlying mechanisms? bit.ly/3IqRkBT

Treatment categorization for chronic rhinosinusitis with nasal polyps has shifted from disease phenotype to inflammatory endotype. How do endotypic differences impact clinical outcomes? An Editors’ Choice study reports new findings. bit.ly/4lpb7A2

While over 50% of U.S. children test positive for common allergens, only ~7% of Amish children do.  Asthma rates run just 1–2% in Amish Children vs. ~8–10% in non-Amish kids. Their secret? See this Washington Post article that cites research from JACI. wapo.st/4odEBmq

An Editors’ Choice study identifies 4 protein modules at the age of 1 year that are associated with the incidence of asthma and/or recurrent wheeze, respiratory infections, and eczema by the age of 6 years. Read on. bit.ly/46R8m5Y

New data associate the dysregulation of cord blood microRNAs (miRNAs) with the development of allergic rhinitis and early childhood asthma. miRNAs may serve as potential noninvasive biomarkers for asthma. The issue includes editorial commentary. bit.ly/4nSSfuY

SARS-CoV-2 revaccination requires immunogenicity and safety data for adjuvanted protein-based vaccines following prior mRNA doses. Findings suggest that the vaccine is safe and produces robust immune responses regardless of prior COVID-19 vaccine history. bit.ly/4mJzY2N

Chimeric antigen receptor (CAR) T and natural killer cell therapies offer a promising strategy for the treatment of cancers and other chronic diseases. Here’s an overview of development, design, and implementation of CAR therapies from bench to bedside. bit.ly/3TFXjVN

Eosinophilic asthma is defined according to blood eosinophil counts and fractional exhaled nitric oxide, but both are limited in their ability to discriminate molecular disease endotypes. What might the future hold? Read a Paradigms and perspectives piece. bit.ly/4lOZu59

Recent evidence has revealed a novel endotype of pediatric asthma: the frequent exacerbator (FE) endotype. Phelan and Hershey provide an overview of its epidemiology, definition, and environmental and clinical associations. bit.ly/3TzRtFn

A study clinically characterizes and functionally tests 34 individuals with IRF2BP2 variants. The data suggest that IRF2BP2 deficiency causes a complex immunodeficiency including gastrointestinal and inflammatory disorders and impaired B-cell maturation. bit.ly/4kphUZZ

The emergence of SARS-CoV-2 Omicron variants led to bivalent vaccine boosters in fall 2022. New findings suggest that the bivalent vaccine induces robust adaptive immune responses and prior SARS-CoV-2 infection provides increased protection. bit.ly/4mOtwHE

The identification of asthma endotypes, and the recognition of multiple subtypes of asthma, is key to personalized treatment strategies. A review discusses asthma endotypes and the ongoing effort to refine diagnostic tools and targeted therapy. bit.ly/4nzCQPQ

Research into the varied immune profiles and molecular signatures of atopic dermatitis has revealed distinct disease endotypes. A review bridges the latest scientific advancements with practical implications for precision medicine. bit.ly/46qaDoy

While chronic spontaneous urticaria has long been classified on the basis of observable clinical features, two chronic spontaneous urticaria (CRU) endotypes have now been characterized. Here’s a review of our current understanding. bit.ly/46oZvZ5

Advances in biomedical technology have revealed complex pathways underlying the pathogenesis of food-allergic disorders. A review proposes and describes a framework for food allergy endotype definition and classification. Learn more. bit.ly/4lDsgFO

New data chronicle the clinical manifestations of a novel IRF8 variant, confirm its pathogenic nature, and specify a dominant-negative mechanism of action. The findings broaden the existing phenotype of IRF8 immunodeficiency. Learn more here. bit.ly/3FnUntq

Prompt diagnosis of severe combined immunodeficiency is critical. A study explores variable factors including the impact of newborn screening associated with hematopoietic stem cell transplantation outcomes and overall survival in a multiethnic cohort. bit.ly/4402HJ4