Imogen Ramsden

SGP25 Session 1 (Part 1): ⛓️ Mapping KRAS interactomes in organoid models 🧬 Isoform-specific KRAS: one mutation, big difference 🔬 Novel tool tracks Ras mutation dynamics in vivo ✨ And a reminder that clear science communication empowers patients! @BiochemSoc #BiochemEvent

Back to back conferences - having wrapped up the Small G proteins meeting, landed in Istanbul heading to the 24th FEBS Young Scientists’ Forum ( #YSF2025 ) held in the stunning region of Sapança! Thanks FEBS for awarding me a YSF travel grant! @FEBSnews #FEBS2025 #BiochemEvent

Final Session 6 SGP2025: 🎯 Biomechanical signatures & potential targets in cancer 🧬 Rho and Cdc42 regulation via PTMs, localisation & degradation in cancer and immunodeficiencies ⚙️ Nuclear force feedback loops via Rnd3 modulate actomyosin tension @BiochemSoc #BiochemEvent

Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase. Looking forward to Session 6 kicked off by @VickySanzMoreno! @BiochemSoc #BiochemEvent

SGP25 Sessions 4 & 5: 🧬 Lipid sensing, β-catenin, and phosphorylation reshape GTPase signalling ⚙️ Mechanical forces & trafficking: nuclear F-actin, actin-Rab27a, plexins, & COL1 ⚡️Cancer cell adaptation through RhoA, Rac1 SUMOylation, and KRAS rewiring @BiochemSoc #BiochemEvent

SGP25 Session 3: Theme of molecular glues… ⛓️ Tri-complex inhibitor as molecular glue for oncogenic RAS 💊 Combining inhibitors to combat KRAS-driven cancer 🎯 p120RasGAP molecular glue targeting RAS 🔢 Mathematical modelling to study RAS activity @BiochemSoc #BiochemEvent

SGP25 Session 2 (Part 2): 🧬 RAP1GDS1 isoform regulates KRAS signalling & lysosomal function in lung adenocarcinoma ❓Oncogenic KRAS may not alter Akt/ERK pathways ☠️ p190RhoGAP paralogs show synthetic lethality in endometrial cancer @BiochemSoc #BiochemEvent

SGP25 Session 1 (Part 2): 🧫 Overcoming RAS resistance: biobanks & precision medicine 💊 Adaptive immunity enhances KRAS inhibitor activity 🔬 Organoids reveal allele-specific tumour growth 💥 Plus ARL15, RhoGDI1, RalGEF, SOS1/2 & proteomics pipelines @BiochemSoc #BiochemEvent

Just kicking off at the Small G Proteins Meeting 2025 after lunch meeting scientists from all over the world - Barcelona, Connecticut, New York - and it’s encouraging to see a programme with both early career researchers and group leaders presenting! @BiochemSoc #BiochemEvent

Excited to be selected as one of the Social Media Contributors at the #BiochemEvent Small G Proteins Meeting next week, thanks to @BiochemSoc. I look forward to hearing about and discussing the latest research in the area as well as presenting my own PhD work about Arf proteins!

🚨 Excited to share my first preprint! 🚨 I developed a bioinformatics pipeline to identify novel drug targets in multidrug-resistant bacteria as part of my Master’s research. Check it out here: biorxiv.org/content/10.110…

A fortnight ago I had the chance to present my PhD research at #Biologists100 — gave a flash talk, presented my poster, and had great chats at the brilliant ECR careers session. Big thanks to @Co_Biologists & @Official_BSCB for the opportunity! 📸 Full post + photos on LinkedIn