Heegwang Roh
@heegwangroh
Postdoc @BerkeleyMCB, PhD @Stanford
Thrilled to continue my interdisciplinary research with @aliceyting as a 2023 Schmidt Science Fellow! A big shout-out to @kevansf for your guidance and support in shaping me as a scientist. Thank you @UCSFGradDiv @UCSF for the nomination. Can't wait to see you all in London!
Our 2023 cohort represents 14 nationalities from 25 Nominating Institutions, with 11 new nominating universities seeing Fellows selected. The cohort includes our first Fellows from Macedonia, Ecuador, Brazil, and Nigeria! Learn more about the 2023 cohort - schmidtsciencefellows.org/news/learn-mor…
I'm honored to have been selected as a JCC postdoctoral Fellow. This will support my research in elucidating the detailed molecular mechanisms of UPR. Huge thanks to my advisors @RapeLab @aliceyting, and collaborators/colleagues for their support! jccfund.org/blog/the-jane-…
Excited to share one of my final projects from PhD! Through rational design and directed evolution, we've engineered LATeNT, a light-inducible protease for neuroscience and synthetic biology. Huge thanks to my advisor @aliceyting, Ji Won Um, Dongwook Kim, and all collaborators.
Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for…
Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for…
I’ve successfully defended my PhD thesis! Huge thanks to my incredible advisor, @aliceyting, for the unwavering support, and to all the amazing tinglab members for creating such a fantastic lab environment. I feel so fortunate to have been a part of the tinglab.

We are recruiting postdocs! Open projects related to enzyme engineering, protein directed evolution, computational protein design, spatial proteomics, RNA tools, and molecular technology development for cell biology and neuroscience. We especially welcome talented postdoc…
LOV-Turbo is published today in @naturemethods and plasmids for LOV-Turbo are available on Addgene, here: addgene.org/browse/article… We hope many people will use LOV-Turbo in exciting new ways! nature.com/articles/s4159… If you plan to use NanoLuc BRET to activate LOV-Turbo, please…
Light-regulated TurboID, or LOV-Turbo, is a feat of engineered allostery, created by @SongyiLee10 and @CheahJoleen via structure-guided design, then optimized by yeast display directed evolution. Activity is nearly undetectable in the dark state, but biorxiv.org/cgi/content/sh……
Excited to share my work @J_A_C_S on using inactivated botulinum toxin for cytosolic delivery of proteins. A big thank you to my advisor @aliceyting, to co-author Prof. Dorner, and to all Tinglab members for making our lab such an enjoyable place to be. pubs.acs.org/doi/10.1021/ja…
It has been a great pleasure being part of this wonderful team!
Light-regulated TurboID, or LOV-Turbo, is a feat of engineered allostery, created by @SongyiLee10 and @CheahJoleen via structure-guided design, then optimized by yeast display directed evolution. Activity is nearly undetectable in the dark state, but biorxiv.org/cgi/content/sh……
We are hiring a full-time lab manager and research scientist to begin in June 2023! Great opportunity for a graduating senior to delve into research before applying to grad school/med school. Candidate will support day-to-day lab operations and participate careersearch.stanford.edu/jobs/life-scie……
“It seemed absolutely crazy. The idea that an Iowa housewife, equipped with the cutting-edge medical tool known as Google Images, would make a medical discovery about a pro athlete who sees doctors and athletic trainers as part of her job?” propublica.org/article/muscul…
My first paper in grad school online today @J_A_C_S!! Very, very big thanks (again here too) to my great coworker/mentor/friend @MatthewRavalin, wonderful advisor @aliceyting, and amazing collaborators @TheOttLab @GladstoneInst and John Pak @czbiohub. pubs.acs.org/doi/10.1021/ja…
My first conference as a PhD student #MAPS2022.Met some awesome scientists, discussed some great science and heard a whole lot of fantastic talks.Thanks to everyone who stopped by my poster. Big thanks to @CeljaUebel for training me and @phillips_lab for being an awesome mentor.
Happy to share my first preprint, a single-component luminescent biosensor for SARS-CoV-2 Spike protein! Huge thanks to my advisor @aliceyting and my coworker/mentor/academic role model @MatthewRavalin . See Matt's thread for details!
Happy to share the @biorxivpreprint for my first bit of work w/ @aliceyting. Together with @heegwangroh, we built a simple and versatile single-component luminescent biosensor for detecting the SARS-CoV-2 spike protein. biorxiv.org/content/10.110…
There are many COVID assays out there, but we tried to build one that is simpler to use and easier/cheaper to manufacture. Our S-BAT sensor is a single recombinant protein that can be expressed from lab strains of E. coli (or yeast), and detects spike antigen or cultured virus…
A single-component luminescent biosensor for the SARS-CoV-2 spike protein biorxiv.org/cgi/content/sh… #bioRxiv
"Here we introduce LuCID, a dual-purpose real-time calcium indicator and transcriptional calcium integrator" Erdenee and @aliceyting's new tool can also read out other cellular events such as protein–protein interactions. pubs.acs.org/doi/full/10.10… @Stanford #calcium #signaling
I spend a lot of time as a #newPI being like—Where can I get a trash can? Who supplies the paper towels? Oh, I have to buy the soap…cool—but trainees like @LatinaNeuroNerd make it WORTH IT! We did our lab’s first surgeries yesterday and she was🔥 This job has its moments ;)
In case you’re wondering, my rotation with @tinakim_neuro is going great 🤩
Twitter, it's my birthday! And there's no better gift than finally getting my job posting approved :D So please help spread the word that The Kim Lab @UCDavisCNS is hiring a research technician/lab manager! Apply below, or reach out with questions (1/2): recruit.ucdavis.edu/JPF04264