Endothelial Cell News

This work out of @ShanghaiTechUni establishes a 3D atlas of #glioma heterogeneity and nanoparticle distribution, and bridges mesoscopic structural complexity to functional drug delivery barriers. | @ScienceAdvances 💡 bit.ly/3TYhFJT

Patient data-based #stenosis models provide a robust platform for studying the effects of vascular geometry on blood flow, #endothelial responses, and platelet aggregation. Learn more from Dr. Beata Wojciak-Stothard and Salina Nicoleau. 🤩 🔗 rsc.li/411mpCo

In clinical esophageal squamous-cell carcinoma samples, Notch-signaling activation scores were significantly correlated with tumor microvascular density, advanced TNM stages, and short patient survival time. | @SciReports 🥼 Find out more: go.nature.com/40xfyR5

🚦 A cluster of Alk1 mutant #endothelial cells with altered arterio-venous identity overexpresses pathways related to fluid shear stress and VEGFR2/phosphoinositide 3-kinase/AKT signaling. | @CircAHA Learn more from Dr. Anne Eichmann and team. 👇 bit.ly/4kVdwRP

This review showcases emerging biomarkers and therapeutic targets that can evaluate endothelial dysfunction across various kidney diseases, namely: acute kidney injury, diabetic kidney disease, polycystic kidney disease, and renal cell carcinoma. 📚 bit.ly/4lGbx5m

Dr. Michele Ciccarelli (@miccic77) and team examined how mitochondrial GRK2 accumulation affects vascular reactivity and #endothelial function in transient hypoxic conditions. 📖 Discover their findings in @cddpress: go.nature.com/4kLCLGs

The Outtz Reed lab and collaborators show that lung lymphatic button junction formation in models of #LungInjury is dependent on the thrombin receptor protease-activated receptor 1. Their study was published today in @NatureCVR. 👇 go.nature.com/4lua8yB

🔥 New in @cellcellpress! Dr. Chenghua Gu and team show that #endothelial gap junction coupling enables long-range propagation of vasodilation signals through the vasculature during #neurovascular coupling. bit.ly/4eU9doJ

Researchers alongside Dr. Raj Kishore (@kishraj2020) identified a key role for skeletal muscle cell-small extracellular vesicles-derived miR-499-5p in the diabetes/ischemia-impaired angiogenic property of #endothelial cells. 💡 Learn more: bit.ly/4lyTn5o

Researchers established sympathetic denervation as a neuroprotective intervention that disrupts stroke-induced catecholamine surges, reducing cerebral infarct volume while improving functional recovery in multiple behavioral paradigms. 👉 go.nature.com/4o5sgAL

Researchers are making ever more sophisticated mini organs in the lab. 🧫 These mini hearts, lungs, and livers can now grow their own #BloodVessels. 📰 Check it out in @Nature: go.nature.com/3GGBQJc

Drs. Hanning Liu and Zhe Zheng have found that targeting endothelial-specific pathways represents a promising therapeutic strategy for attenuating atrial fibrosis in #AtrialFibrillation pathogenesis. Abstract in European Heart Journal: bit.ly/3GkI8OJ

#Atherosclerosis is partly characterized by endothelial dysfunction and inflammation. A new study explored the application of remdesivir, an antiviral agent, and found that it impedes atherosclerosis progression by diminishing endothelial activation: bit.ly/44AvZNv

🚨 New review alert! Repairing and protecting the blood brain barrier (BBB) is a new avenue for controlling epileptic seizures and treating drug‑resistant epilepsy. This paper does a deep dive into the BBB's role in pathogenesis and future treatments: bit.ly/4kpEpND

🫁 Recent studies have highlighted endothelial cells as contributors to #PulmonaryFibrosis (PF). Now, the Greco lab (@dariog_helsinki) has provided a blueprint of early pro-fibrotic mechanisms via the endothelium that contributes towards PF pathogenesis: go.nature.com/4lHeiCO

Drs. @Irtisha_Singh and @AKGaharwar from @TAMU have made new strides in the wound healing process. Nanosilicates, a proangiogenic biomaterial, can help speed up red blood cell development and graft #vascularization in vivo! Abstract in @ScienceAdvances: bit.ly/44Et8n0

Drs. @AKGaharwar, @Irtisha_Singh, and colleagues at @bmentamu provide mechanistic insights into how nanosilicates stimulate proangiogenic behavior in #endothelial cells, addressing a longstanding knowledge gap in their role in #angiogenesis. 🔓 bit.ly/44Et8n0

In this recent @SciReports article, scientists identified distinct subpopulations of #endothelial cells and elucidated their potential roles in primary biliary #cholangitis development and therapeutic response. 💡 Learn more: go.nature.com/45YTe6t

Collaborators found that the interaction between VAMP3 on TfR vesicles and syntaxin 4 at the basolateral membrane of brain microvascular #endothelial cells mediates the final fusion step of TfR transcytosis. 📍 Now in @PNASNews! bit.ly/3Ip9VOm

At Peking University, scientists found that TGF-β signaling is hyperactive in dysfunctional aplastic #anemia #endothelial progenitor cells with impaired #hematopoietic support and immune regulatory ability. 📝 go.nature.com/4kjv6Pl